Increased COVID-19 Mortality and Deficient SARS-CoV-2 Immune Response Are Not Associated with Higher Levels of Endemic Coronavirus Antibodies

被引:2
|
作者
Adhikari, Bindu [1 ,2 ]
Oltz, Eugene M. [3 ]
Bednash, Joseph S. [4 ]
Horowitz, Jeffrey C. [4 ]
Amimo, Joshua O. [2 ]
Raev, Sergei A. [2 ]
Fernandez, Soledad [5 ,6 ]
Anghelina, Mirela [5 ,6 ]
Liu, Shan-Lu [3 ,7 ,8 ,9 ]
Rubinstein, Mark P. [10 ,11 ]
Jones, Daniel M. [12 ]
Saif, Linda J. [1 ,2 ]
Vlasova, Anastasia N. [1 ,2 ]
机构
[1] Ohio State Univ, Coll Vet Med, Dept Vet Prevent Med, Wooster, OH 44691 USA
[2] Ohio State Univ, Coll Food Agr & Environm Sci, Ctr Food Anim Hlth, Dept Anim Sci,OARDC, Wooster, OH 44691 USA
[3] Ohio State Univ, Dept Microbial Infect & Immun, Columbus, OH 43210 USA
[4] Ohio State Univ, Dept Internal Med, Div Pulm Crit Care & Sleep Med, Columbus, OH 43210 USA
[5] Ohio State Univ, Coll Med, Dept Biomed Informat, Columbus, OH 43210 USA
[6] Ohio State Univ, Ctr Biostat, Columbus, OH 43210 USA
[7] Ohio State Univ, Ctr Retrovirus Res, Columbus, OH 43210 USA
[8] Ohio State Univ, Dept Vet Biosci, Columbus, OH 43210 USA
[9] Ohio State Univ, Infect Dis Inst, Viruses & Emerging Pathogens Program, Columbus, OH 43210 USA
[10] Ohio State Univ, Dept Internal Med, Div Med Oncol, Columbus, OH 43210 USA
[11] Ohio State Univ, Pelotonia Inst Immunooncol, James Comprehens Canc Ctr, Columbus, OH 43210 USA
[12] Ohio State Univ, Dept Pathol, Columbus, OH 43210 USA
来源
IMMUNO | 2023年 / 3卷 / 03期
关键词
SARS-CoV-2; common cold coronavirus; serological testing; immunocompromised patients; antibodies;
D O I
10.3390/immuno3030020
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The impact of pre-existing common cold coronavirus (CCCoV) antibodies (Abs) on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immune responses and pathogenesis remains poorly defined. We evaluated these associations in a cohort of hospitalized patients with COVID-19 and respiratory failure of varying severity. Patients with respiratory failure from other causes (non-COVID-19) were evaluated as controls. We demonstrated a positive correlation between levels of CCCoV and SARS-CoV-2 Abs using CCCoV and SARS-CoV-2 N and S protein peptide-specific ELISA. Consistent with the above, moderately increased levels of CCCoV-specific Abs in non-COVID-19 vs. COVID-19 patients suggest potential protective effects. Further, higher SARS-CoV-2 N protein-specific and CCCoV Ab levels were observed among surviving vs. non-surviving COVID-19 positive patients. However, the highest SARS-CoV-2 N and S protein-specific IgG and IgA Ab levels were noted in the patients with the most severe clinical disease. Finally, advanced age, cancer and immunosuppression were associated with significantly higher mortality and reduced SARS-CoV-2 and CCCoV Ab levels. Thus, our data highlight that sufficient SARS-CoV-2 N protein-specific Ab responses improve clinical outcomes in severely ill COVID-19 patients. We also confirmed that pre-existing CCCoV-specific Abs do not inhibit the SARS-CoV-2 Ab response and may further reduce the prevalence and/or severity of COVID-19.
引用
收藏
页码:330 / 345
页数:16
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