The number of published studies on curcuminoids in cancer research, including its lead molecule curcumin and synthetic analogs, has been increasing substantially during the past two decades. Insights on the diversity of inhibitory effects they have produced on a multitude of pathways involved in carcinogenesis and tumor progression have been provided. As this wealth of data was obtained in settings of various experimental and clinical data, this review first aimed at presenting a chronology of discoveries and an update on their complex in vivo effects. Secondly, there are many interesting questions linked to their pleiotropic effects. One of them, a growing research topic, relates to their ability to modulate metabolic reprogramming. This review will also cover the use of curcuminoids as chemosensitizing molecules that can be combined with several anticancer drugs to reverse the phenomenon of multidrug resistance. Finally, current investigations in these three complementary research fields raise several important questions that will be put among the prospects for the future research related to the importance of these molecules in cancer research.
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Chiang Mai Univ, Dept Physiol, Cardiac Electrophysiol Unit, Chiang Mai, Thailand
Chiang Mai Univ, Fac Med, Cardiac Electrophysiol Res & Training Ctr, Chiang Mai, Thailand
Chiang Mai Univ, Ctr Excellence Cardiac Electrophysiol Res, Chiang Mai, ThailandChiang Mai Univ, Dept Physiol, Cardiac Electrophysiol Unit, Chiang Mai, Thailand
Thonusin, Chanisa
Nawara, Wichwara
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Chiang Mai Univ, Fac Med, Cardiac Electrophysiol Res & Training Ctr, Chiang Mai, Thailand
Chiang Mai Univ, Ctr Excellence Cardiac Electrophysiol Res, Chiang Mai, ThailandChiang Mai Univ, Dept Physiol, Cardiac Electrophysiol Unit, Chiang Mai, Thailand
Nawara, Wichwara
Arinno, Apiwan
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Chiang Mai Univ, Dept Physiol, Cardiac Electrophysiol Unit, Chiang Mai, Thailand
Chiang Mai Univ, Fac Med, Cardiac Electrophysiol Res & Training Ctr, Chiang Mai, Thailand
Chiang Mai Univ, Ctr Excellence Cardiac Electrophysiol Res, Chiang Mai, ThailandChiang Mai Univ, Dept Physiol, Cardiac Electrophysiol Unit, Chiang Mai, Thailand
Arinno, Apiwan
Khuanjing, Thawatchai
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Chiang Mai Univ, Dept Physiol, Cardiac Electrophysiol Unit, Chiang Mai, Thailand
Chiang Mai Univ, Fac Med, Cardiac Electrophysiol Res & Training Ctr, Chiang Mai, Thailand
Chiang Mai Univ, Ctr Excellence Cardiac Electrophysiol Res, Chiang Mai, ThailandChiang Mai Univ, Dept Physiol, Cardiac Electrophysiol Unit, Chiang Mai, Thailand
Khuanjing, Thawatchai
Prathumsup, Nanthip
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Chiang Mai Univ, Dept Physiol, Cardiac Electrophysiol Unit, Chiang Mai, Thailand
Chiang Mai Univ, Fac Med, Cardiac Electrophysiol Res & Training Ctr, Chiang Mai, Thailand
Chiang Mai Univ, Ctr Excellence Cardiac Electrophysiol Res, Chiang Mai, ThailandChiang Mai Univ, Dept Physiol, Cardiac Electrophysiol Unit, Chiang Mai, Thailand
Prathumsup, Nanthip
Ongnok, Benjamin
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Chiang Mai Univ, Dept Physiol, Cardiac Electrophysiol Unit, Chiang Mai, Thailand
Chiang Mai Univ, Fac Med, Cardiac Electrophysiol Res & Training Ctr, Chiang Mai, Thailand
Chiang Mai Univ, Ctr Excellence Cardiac Electrophysiol Res, Chiang Mai, ThailandChiang Mai Univ, Dept Physiol, Cardiac Electrophysiol Unit, Chiang Mai, Thailand
Ongnok, Benjamin
Chattipakorn, Siriporn C.
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Chiang Mai Univ, Fac Med, Cardiac Electrophysiol Res & Training Ctr, Chiang Mai, Thailand
Chiang Mai Univ, Ctr Excellence Cardiac Electrophysiol Res, Chiang Mai, Thailand
Chiang Mai Univ, Fac Dent, Dept Oral Biol & Diagnost Sci, Chiang Mai, ThailandChiang Mai Univ, Dept Physiol, Cardiac Electrophysiol Unit, Chiang Mai, Thailand