Metabolic and Biochemical Effects of Pyrroloquinoline Quinone (PQQ) on Inflammation and Mitochondrial Dysfunction: Potential Health Benefits in Obesity and Future Perspectives

被引：1

作者：

Charrier, Davide ^{[1
]}

Cerullo, Giuseppe ^{[1
]}

Carpenito, Roberta ^{[2
]}

Vindigni, Vincenzo ^{[2
]}

Bassetto, Franco ^{[2
]}

Simoni, Luca ^{[1
]}

Moro, Tatiana ^{[1
]}

Paoli, Antonio ^{[1
,3
]}

机构：

[1] Univ Padua, Dept Biomed Sci, I-35122 Padua, Italy

[2] Univ Padua, Dept Neurosci, Plast & Reconstruct Surg Unit, I-35122 Padua, Italy

[3] UCAM Catholic Univ Murcia, Res Ctr High Performance Sport, Murcia 30107, Spain

来源：

ANTIOXIDANTS | 2024年 / 13卷 / 09期

关键词：

pyrroloquinoline quinone (PQQ); adipose tissue; oxidative stress; inflammation; mitochondrial dysfunction; OXIDATIVE STRESS; SKELETAL-MUSCLE; DISODIUM SALT; PHYSIOLOGICAL IMPORTANCE; HEART-FAILURE; INJURY; RESISTANCE; ATROPHY; MASS;

D O I：

10.3390/antiox13091027

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Obesity is defined as a complex, systemic disease characterized by excessive and dysfunctional adipose tissue, leading to adverse health effects. This condition is marked by low-grade inflammation, oxidative stress, and metabolic abnormalities, including mitochondrial dysfunction. These factors promote energy dysregulation and impact body composition not only by increasing body fat but also by promoting skeletal muscle mass atrophy. The decline in muscle mass is associated with an increased risk of all-cause mortality in individuals with this disease. The European Food Safety Authority approved pyrroloquinoline quinone (PQQ), a natural compound, as a dietary supplement in 2018. This narrative review aims to provide a comprehensive overview of the potential role of PQQ, based on its anti-inflammatory and antioxidant properties, in addressing dysfunctional adipose tissue metabolism and related disorders.

引用

页数：13