Towards more accurate pharmacogenomic variant effect predictions

被引：1
|
作者：
Park, Yoomi [1 ,2 ]
M Lauschke, Volker [3 ,4 ,5 ]
机构：
[1] Seoul Natl Univ, Coll Med, Seoul Natl Univ Biomed Informat SNUBI, Seoul, South Korea
[2] Seoul Natl Univ, Coll Med, Med Res Ctr, Seoul, South Korea
[3] Dr Margarete F Bosch Inst Clin Pharmacol, Stuttgart, Germany
[4] Karolinska Inst, Dept Physiol & Pharmacol, Stockholm, Sweden
[5] Univ Tubingen, Tubingen, Germany
来源：
PHARMACOGENOMICS | 2023年 / 24卷 / 16期
关键词：
Genomic Medicine; Personalized Drug Response; Precision Medicine; Variant of unknown significance;
D O I：
10.2217/pgs-2023-0187
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Accurate variant interpretation has become a key bottleneck for the translation of an individual's pharmacogenome into actionable recommendations. We recommend an integrated use of multiplexed assays, structure-based predictions and biobank data to develop more accurate effect predictors.
引用
收藏
页码：841 / 844
页数：4
相关论文
共 50 条
  • [21] Composite approach towards accurate predictions of lanthanide and actinide thermochemistry
    Peterson, Charles
    Penchoff, Deborah
    Wilson, Angela
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2016, 251
  • [22] More accurate or less accurate: How does maximization orientation affect task completion predictions?
    Zhu, Dongqing
    Li, Xue
    Yang, Shan
    Xie, Xiaofei
    PERSONALITY AND INDIVIDUAL DIFFERENCES, 2019, 137 : 173 - 183
  • [23] Successful Explanations Start with Accurate Descriptions: Questionnaire Items as Personality Markers for More Accurate Predictions
    Seeboth, Anne
    Mottus, Rene
    EUROPEAN JOURNAL OF PERSONALITY, 2018, 32 (03) : 186 - 201
  • [24] Extensions to the halo occupation distribution model for more accurate clustering predictions
    Jimenez, Esteban
    Contreras, Sergio
    Padilla, Nelson
    Zehavi, Idit
    Baugh, Carlton M.
    Gonzalez-Perez, Violeta
    MONTHLY NOTICES OF THE ROYAL ASTRONOMICAL SOCIETY, 2019, 490 (03) : 3532 - 3544
  • [25] Faster and more accurate pathogenic combination predictions with VarCoPP2.0
    Nassim Versbraegen
    Barbara Gravel
    Charlotte Nachtegael
    Alexandre Renaux
    Emma Verkinderen
    Ann Nowé
    Tom Lenaerts
    Sofia Papadimitriou
    BMC Bioinformatics, 24
  • [26] Faster and more accurate pathogenic combination predictions with VarCoPP2.0
    Versbraegen, Nassim
    Gravel, Barbara
    Nachtegael, Charlotte
    Renaux, Alexandre
    Verkinderen, Emma
    Nowe, Ann
    Lenaerts, Tom
    Papadimitriou, Sofia
    BMC BIOINFORMATICS, 2023, 24 (01)
  • [27] QSAR models for bioconcentration: Is the increase in the complexity justified by more accurate predictions?
    Grisoni, Francesca
    Consonni, Viviana
    Villa, Sara
    Vighi, Marco
    Todeschini, Roberto
    CHEMOSPHERE, 2015, 127 : 171 - 179
  • [28] Towards more accurate unit commitment performance comparisons
    Leanez, Frank
    Palma-Behnke, Rodrigo
    2006 IEEE/PES TRANSMISSION & DISTRIBUTION CONFERENCE & EXPOSITION: LATIN AMERICA, VOLS 1-3, 2006, : 1590 - +
  • [29] Towards more accurate prognostication after preterm birth
    Morgan, Catherine
    DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY, 2018, 60 (12): : 1194 - 1195
  • [30] TOWARDS MORE ACCURATE BLOOD-PRESSURE READINGS
    ABELSON, D
    JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1974, 227 (12): : 1381 - 1381
12345