Engineered Vancomycin, with Increased Interactions with Peptidoglycan Stem Peptide, Conquers Non-tuberculosis Mycobacteria

被引：0

作者：

Vennard, Christopher ^{[1
,2
]}

Oropo, Temitope ^{[1
]}

Sintim, Herman O. ^{[1
,2
,3
]}

机构：

[1] Purdue Univ, Dept Chem, W Lafayette, IN 47907 USA

[2] Purdue Univ, Purdue Inst Inflammat Immunol & Infect Dis, W Lafayette, IN 47907 USA

[3] Purdue Univ, Inst Drug Discovery, W Lafayette, IN 47907 USA

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2023年 / 66卷 / 15期

关键词：

D O I：

10.1021/acs.jmedchem.3c01219

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Vancomycin-like drugs target peptidoglycan (PG) via binding to C-terminal d-Ala-d-Ala dipeptide. An engineered vancomycin has enhanced affinity for the PG stem peptide, due to probable interactions with a third residue, meso-diaminopimelic acid, in the PG. This engineered vancomycin displays enhanced killing of mycobacteria.

引用

页码：10238 / 10240

页数：3

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