Engineered Vancomycin, with Increased Interactions with Peptidoglycan Stem Peptide, Conquers Non-tuberculosis Mycobacteria

被引：0
|
作者：
Vennard, Christopher [1 ,2 ]
Oropo, Temitope [1 ]
Sintim, Herman O. [1 ,2 ,3 ]
机构：
[1] Purdue Univ, Dept Chem, W Lafayette, IN 47907 USA
[2] Purdue Univ, Purdue Inst Inflammat Immunol & Infect Dis, W Lafayette, IN 47907 USA
[3] Purdue Univ, Inst Drug Discovery, W Lafayette, IN 47907 USA
来源：
JOURNAL OF MEDICINAL CHEMISTRY | 2023年 / 66卷 / 15期
关键词：
D O I：
10.1021/acs.jmedchem.3c01219
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Vancomycin-like drugs target peptidoglycan (PG) via binding to C-terminal d-Ala-d-Ala dipeptide. An engineered vancomycin has enhanced affinity for the PG stem peptide, due to probable interactions with a third residue, meso-diaminopimelic acid, in the PG. This engineered vancomycin displays enhanced killing of mycobacteria.
引用
收藏
页码：10238 / 10240
页数：3
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