The 17th EFMC Short Course on Medicinal Chemistry on Small Molecule Protein Degraders

被引：3

作者：

Ciulli, Alessio ^{[1
]}

O'Connor, Suzanne ^{[1
]}

Chung, Chun-Wa ^{[2
]}

Hartung, Ingo V. ^{[3
]}

Testa, Andrea ^{[4
]}

Daniels, Danette L. ^{[5
]}

Heitman, Laura H. ^{[6
]}

机构：

[1] Univ Dundee, Ctr Targeted Prot Degradat, Sch Life Sci, 1 James Lindsay Pl, Dundee DD1 5JJ, Scotland

[2] GlaxoSmithKline Res & Dev Ltd, Gunnelswood Rd, Stevenage SG5 4HT, England

[3] Merck Healthcare KGaA, Frankfurter Str 250, D-64293 Darmstadt, Germany

[4] Amphista Therapeut Ltd, Cori Bldg,Granta Pk, Cambridge CB21 6GQ, England

[5] Foghorn Therapeut, 500 Technol Sq, Cambridge, MA 02139 USA

[6] Leiden Acad Ctr Drug Res LACDR, Oncode Inst, Div Drug Discovery & Safety, POB 9502, NL-2300RA Leiden, Netherlands

来源：

CHEMMEDCHEM | 2023年 / 18卷 / 20期

关键词：

medicinal chemistry; molecular glues; PROTACs; protein degraders; drug design; STRUCTURAL BASIS; DEGRADATION; PROTACS;

D O I：

10.1002/cmdc.202300464

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The 17th EFMC Short Course on Medicinal Chemistry took place April 23-26, 2023 in Oegstgeest, near Leiden in the Netherlands. It covered for the first time the exciting topic of Targeted Protein Degradation (full title: Small Molecule Protein Degraders: A New Opportunity for Drug Design and Development). The course was oversubscribed, with 35 attendees and 6 instructors mainly from Europe but also from the US and South Africa, and representing both industry and academia. This report summarizes the successful event, key lectures given and topics discussed.

引用

页数：7

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