The 17th annual PepTalk meeting organized by Cambridge Healthtech Institute (CHI) was dedicated to proteins, covering their engineering, production and their applications in medicine. The meeting comprised seven parallel tracks entitled: 'Protein Engineering & Development', 'Antibody Therapeutics', 'Innovation in Discovery and Development', 'Formulation & Stability', 'Analytics & Impurities', 'Process Technologies & Purification' and a mixed stream addressing 'Biotherapeutic Expression & Production' and 'Alternative Expression & Production'. Approximately 1,300 attendees were spread across the different sessions. The event also included 'Buzz Sessions', in which highly specialized topics were addressed in round-table discussions. Additionally more than 150 posters were on display, located close to an exhibition with approximately 100 booths of various suppliers for protein research. The 14th installment of the 'Recombinant Protein Therapeutics' conference with the subtitle 'Fusion Proteins & Beyond' was held in the 'Protein Engineering & Development' stream, and is covered in the first part of this report. The rest of the report highlights therapeutic antibodies to treat cancer talks within the 'Protein Engineering & Development' and 'Antibody Therapeutics' tracks at PepTalk.