Delivery of proton FLASH at the TRIUMF Proton Therapy Research Centre

被引：3

作者：

Belanger-Champagne, Camille ^{[1
]}

Roddy, David ^{[1
,2
]}

Penner, Crystal ^{[1
]}

Tattenberg, Sebastian ^{[1
,3
]}

Trinczek, Michael ^{[1
]}

Yen, Stan ^{[1
]}

Blackmore, Ewart ^{[1
]}

Hoehr, Cornelia ^{[1
]}

机构：

[1] TRIUMF, 4004 Wesbrook Mall, Vancouver, BC V6T 2A3, Canada

[2] Univ Edinburgh, Edinburgh EH9 3FD, Scotland

[3] NOSM Univ, Sudbury, ON P3E 2C6, Canada

来源：

NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT | 2023年 / 1052卷

关键词：

FLASH radiotherapy; Proton therapy; Beam delivery; Ridge filter; Proton energy modulation; DESIGN;

D O I：

10.1016/j.nima.2023.168243

中图分类号：

TH7 [仪器、仪表];

学科分类号：

0804 ; 080401 ; 081102 ;

摘要：

The TRIUMF particle accelerator center in Vancouver, British Columbia, Canada houses a proton therapy beam line formerly used for the treatment of ocular cancer. This existing Proton Therapy Research Centre (PTRC) was upgraded to deliver protons at ultra-high dose rates which would be required for FLASH radiotherapy treatments. A peak dose rate of 110 Gy/s over an area of 20 mm2 was delivered at a beam energy of 21 MeV. This was achieved by degrading the cyclotron extracted beam energy of 70 MeV using polymethyl methacrylate (PMMA) plates. In addition, a fast, versatile and reliable method for producing static ridge filters has been developed to spread the proton beam to the entirety of the target axially (i.e., in depth). FLASH dose rates were maintained with a spread-out Bragg peak of 0.5 cm.

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页数：8

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