Total Synthesis of Dragmacidins G and H

被引：1

作者：

Yamazaki, Keita ^{[1
]}

Okuda, Yuma ^{[1
]}

Takaya, Akiko ^{[1
]}

Nemoto, Tetsuhiro ^{[1
]}

机构：

[1] Chiba Univ, Grad Sch Pharmaceut Sci, Chiba 2608675, Japan

来源：

ORGANIC LETTERS | 2024年 / 26卷 / 03期

关键词：

ASYMMETRIC TOTAL-SYNTHESIS; 1ST TOTAL-SYNTHESIS; SPONGE; (+/-)-DRAGMACIDIN; ELUCIDATION;

D O I：

10.1021/acs.orglett.3c04039

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The total synthesis of dragmacidins G and H was achieved for the first time by employing nucleophilic aromatic substitution and site-selective cross-coupling reactions using appropriately functionalized pyrazines as substrates. The evaluation of antibacterial activities of dragmacidin G, dragmacidin H, and synthetic analogues against Staphylococcus aureus and the efflux pump-deficient Salmonella Typhimurium revealed that the presence of a Br group on the indole ring adjacent to the sulfide unit was important for increasing antibacterial activities.

引用

页码：670 / 675

页数：6

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