Targeting AAV Vectors to the CNS via De Novo Engineered Capsid-Receptor Interactions

被引：0

作者：

Huang, Qin ^{[1
]}

Chen, Albert ^{[2
]}

Chan, Ken Y. ^{[1
]}

Sorensen, Hikari ^{[1
]}

Barry, Andrew J. ^{[1
]}

Azari, Bahar ^{[3
]}

Beddow, Thomas ^{[1
]}

Zheng, Qingxia ^{[1
]}

Zhao, Binhui ^{[1
]}

Tobey, Isabelle G. ^{[1
]}

Eid, Fatma Elzahraa ^{[1
]}

Chan, Alina ^{[1
]}

Deverman, Benjamin E. ^{[1
]}

机构：

[1] Broad Inst MIT & Harvard, Cambridge, MA USA

[2] Harvard Univ, Cambridge, MA USA

[3] Northeastern Univ, Elect & Comp Engn Dept, Boston, MA USA

来源：

MOLECULAR THERAPY | 2023年 / 31卷 / 04期

关键词：

D O I：

暂无

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

441

引用

页码：228 / 229

页数：2

共 50 条

[31] Directed Evolution of Rationally-Engineered AAV Capsid Variants with Enhanced Central Nervous System (CNS) Tropism Following Systematic Administration
Wang, Hongxing
Zhu, Sha
Zhang, Weiqun
Toro, Gabriela C.
Liu, Na
Zhao, Lingzhi
Shen, Joan
MOLECULAR THERAPY, 2024, 32 (04) : 480 - 480
[32] Change in capsid-HSPG interaction through peptide insertion in variable loop VIII in liver-targeting AAV vectors
Ertelt, M.
Meumann, N.
Buening, H.
Schoeder, C. T.
HUMAN GENE THERAPY, 2021, 32 (19-20) : A32 - A32
[33] Mosaic vectors comprised of modified AAV1 capsid proteins for efficient vector purification and targeting to vascular endothelial cells
M D Stachler
J S Bartlett
Gene Therapy, 2006, 13 : 926 - 931
[34] Mosaic vectors comprised of modified AAV1 capsid proteins for efficient vector purification and targeting to vascular endothelial cells
Stachler, M. D.
Bartlett, J. S.
GENE THERAPY, 2006, 13 (11) : 926 - 931
[35] De novo-designed transmembrane domains tune engineered receptor functions
Elazar, Assaf
Chandler, Nicholas J.
Davey, Ashleigh S.
Weinstein, Jonathan Y.
Nguyen, Julie, V
Trenker, Raphael
Cross, Ryan S.
Jenkins, Misty R.
Call, Melissa J.
Call, Matthew E.
Fleishman, Sarel J.
ELIFE, 2022, 11
[36] Capsid-Glycan Receptor Interactions Influence AAV Transport across the Blood-Brain Barrier
Albright, Blake H.
Storey, Claire
Devlin, Garth
Agbandje-McKenna, Mavis
Asokan, Aravind
MOLECULAR THERAPY, 2018, 26 (05) : 29 - 29
[37] Versatile de Novo Enzyme Activity in Capsid Proteins from an Engineered M13 Bacteriophage Library
Casey, John P., Jr.
Barbero, Roberto J.
Heldman, Nimrod
Belcher, Angela M.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2014, 136 (47) : 16508 - 16514
[38] Engineered AAV vector minimizes in vivo targeting of transduced hepatocytes by capsid-specific CD8+ T cells
Martino, Ashley T.
Basner-Tschakarjan, Etiena
Markusic, David M.
Finn, Jonathan D.
Hinderer, Christian
Zhou, Shangzhen
Ostrov, David A.
Srivastava, Arun
Ertl, Hildegund C. J.
Terhorst, Cox
High, Katherine A.
Mingozzi, Federico
Herzog, Roland W.
BLOOD, 2013, 121 (12) : 2224 - 2233
[39] Identification of Novel Vectors Capable of CNS Transduction in Adult Mice after Single Round Selection Using DNA Shuffled AAV Capsid Library
Choudhury, Sourav
Maitland, Stacy
Ferreira, Jennifer
Sena-Esteves, Miguel
MOLECULAR THERAPY, 2013, 21 : S1 - S1
[40] De novo design of nonpeptidic compounds targeting the interactions between interferon-α and its cognate cell surface receptor
Bello, Angelica M.
Bende, Tanushree
Wei, Lianhu
Wang, Xiaoyang
Majchrzak-Kita, Beata
Fish, Eleanor N.
Kotra, Lakshmi P.
JOURNAL OF MEDICINAL CHEMISTRY, 2008, 51 (09) : 2734 - 2743

← 1 2 3 4 5 →