Lactoferrin Has a Protective Effect on Mouse Brain Cells after Acute Gamma Irradiation of the Head

被引：1

作者：

Kopaeva, M. Yu. ^{[1
]}

Cherepov, A. B. ^{[1
,2
]}

Zaraiskaya, I. Yu. ^{[3
]}

机构：

[1] Kurchatov Inst, Natl Res Ctr, Moscow, Russia

[2] Res Inst Gen Pathol & Pathophysiol, Moscow, Russia

[3] PK Anokhin Res Inst Normal Physiol, Moscow, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2023年 / 176卷 / 02期

关键词：

human lactoferrin; acute gamma irradiation of the head; dentate gyrus of the hippocampus; cellular proliferation; TUNEL; DENTATE GYRUS; IONIZING-RADIATION; ADULT; EXPRESSION; APOPTOSIS; DAMAGE;

D O I：

10.1007/s10517-024-06004-3

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

We studied the effect of human lactoferrin on cells of the hippocampal dentate gyrus of 2-2.5-month-old male C57BL/6 mice after acute gamma irradiation of the head in a dose of 8 Gy from a 60Co source. Immediately after irradiation some animals received an intraperitoneal injection of human lactoferrin (4 mg/mouse). The appearance of TUNEL+ cells in the subgranular zone 6 h after irradiation was accompanied by a corresponding decrease in the number of Ki-67- and DCX-immunoreactive cells. Administration of lactoferrin had a protective effect on mouse brain cells, which manifested in a decrease in the number of TUNEL+ cells (by 77% relative to the irradiation alone) and an increase in the number of proliferating cells (from 16 to 61% relative to control animals) and immature neurons (from 14 to 22% relative to control animals) in the dentate gyrus of the hippocampus.

引用

页码：232 / 234

页数：3

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