Lactoferrin Has a Protective Effect on Mouse Brain Cells after Acute Gamma Irradiation of the Head

被引：1
|
作者：
Kopaeva, M. Yu. [1 ]
Cherepov, A. B. [1 ,2 ]
Zaraiskaya, I. Yu. [3 ]
机构：
[1] Kurchatov Inst, Natl Res Ctr, Moscow, Russia
[2] Res Inst Gen Pathol & Pathophysiol, Moscow, Russia
[3] PK Anokhin Res Inst Normal Physiol, Moscow, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2023年 / 176卷 / 02期
关键词：
human lactoferrin; acute gamma irradiation of the head; dentate gyrus of the hippocampus; cellular proliferation; TUNEL; DENTATE GYRUS; IONIZING-RADIATION; ADULT; EXPRESSION; APOPTOSIS; DAMAGE;
D O I：
10.1007/s10517-024-06004-3
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
We studied the effect of human lactoferrin on cells of the hippocampal dentate gyrus of 2-2.5-month-old male C57BL/6 mice after acute gamma irradiation of the head in a dose of 8 Gy from a 60Co source. Immediately after irradiation some animals received an intraperitoneal injection of human lactoferrin (4 mg/mouse). The appearance of TUNEL+ cells in the subgranular zone 6 h after irradiation was accompanied by a corresponding decrease in the number of Ki-67- and DCX-immunoreactive cells. Administration of lactoferrin had a protective effect on mouse brain cells, which manifested in a decrease in the number of TUNEL+ cells (by 77% relative to the irradiation alone) and an increase in the number of proliferating cells (from 16 to 61% relative to control animals) and immature neurons (from 14 to 22% relative to control animals) in the dentate gyrus of the hippocampus.
引用
收藏
页码：232 / 234
页数：3
相关论文
共 50 条
  • [21] Exogenous deoxyribonuclease has a protective effect in a mouse model of sepsis
    Laukova, Lucia
    Konecna, Barbora
    Babickova, Janka
    Wagnerova, Alexandra
    Meliskova, Veronika
    Vlkova, Barbora
    Celec, Peter
    BIOMEDICINE & PHARMACOTHERAPY, 2017, 93 : 8 - 16
  • [22] PROTECTIVE EFFECT OF LACTOFERRIN ON CERULEIN-INDUCED ACUTE-PANCREATITIS IN RATS
    KOIKE, D
    MAKINO, I
    DIGESTION, 1993, 54 (02) : 84 - 90
  • [23] PROTECTIVE EFFECT OF FOLCYSTEINE AGAINST ACUTE IRRADIATION INSULTS
    OERIE, S
    HRSCOVIC.H
    SINGER, D
    GANE, P
    ARZNEIMITTEL-FORSCHUNG, 1967, 17 (10): : 1336 - &
  • [24] Melatonin as a protective agent in spinal cord damage after gamma irradiation
    Aghazadeh, Sara
    Azarnia, Mahnaz
    Shirazi, Alireza
    Mahdavi, Seied Rabie
    Zangii, Bagher Minaee
    REPORTS OF PRACTICAL ONCOLOGY AND RADIOTHERAPY, 2007, 12 (02) : 95 - 99
  • [25] DYNAMICS OF MICRONUCLEI IN MOUSE SKIN FIBROBLASTS AFTER GAMMA IRRADIATION
    Kaspler, Pavel
    Hyrien, Ollivier
    Hill, Richard P.
    HEALTH PHYSICS, 2010, 98 (02): : 228 - 233
  • [26] EFFECT OF GAMMA-IRRADIATION ON CHOLESTEROL OF CHICKEN BRAIN
    BAWA, SR
    MITTAL, B
    STRAHLENTHERAPIE, 1976, 151 (02) : 162 - 164
  • [27] Radioprotective effect of grape seed extract against gamma irradiation in mouse bone marrow cells
    Targhi, Reza Ghasemnezhad
    Banaei, Amin
    Saba, Valiallah
    JOURNAL OF CANCER RESEARCH AND THERAPEUTICS, 2019, 15 (03) : 512 - 516
  • [28] EFFECT OF ACUTE GAMMA-IRRADIATION OF MEADOW VEGETATION
    SMIRNOV, EG
    SHEIN, GP
    GURO, NV
    MALTSEVA, LN
    SOVIET JOURNAL OF ECOLOGY, 1983, 14 (06) : 329 - 332
  • [29] Interferon has no protective effect during acute or persistent reovirus infection of mouse SC1 fibroblasts
    Danis, C
    Mabrouk, T
    Faure, M
    Lemay, G
    VIRUS RESEARCH, 1997, 51 (02) : 139 - 149
  • [30] Histological changes in the normal rat brain after gamma irradiation
    Kamiryo, T
    Kassell, NF
    Thai, QA
    Lopes, MBS
    Lee, KS
    Steiner, L
    ACTA NEUROCHIRURGICA, 1996, 138 (04) : 451 - 459
12345