Lactoferrin Has a Protective Effect on Mouse Brain Cells after Acute Gamma Irradiation of the Head

被引：1
|
作者：
Kopaeva, M. Yu. [1 ]
Cherepov, A. B. [1 ,2 ]
Zaraiskaya, I. Yu. [3 ]
机构：
[1] Kurchatov Inst, Natl Res Ctr, Moscow, Russia
[2] Res Inst Gen Pathol & Pathophysiol, Moscow, Russia
[3] PK Anokhin Res Inst Normal Physiol, Moscow, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2023年 / 176卷 / 02期
关键词：
human lactoferrin; acute gamma irradiation of the head; dentate gyrus of the hippocampus; cellular proliferation; TUNEL; DENTATE GYRUS; IONIZING-RADIATION; ADULT; EXPRESSION; APOPTOSIS; DAMAGE;
D O I：
10.1007/s10517-024-06004-3
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
We studied the effect of human lactoferrin on cells of the hippocampal dentate gyrus of 2-2.5-month-old male C57BL/6 mice after acute gamma irradiation of the head in a dose of 8 Gy from a 60Co source. Immediately after irradiation some animals received an intraperitoneal injection of human lactoferrin (4 mg/mouse). The appearance of TUNEL+ cells in the subgranular zone 6 h after irradiation was accompanied by a corresponding decrease in the number of Ki-67- and DCX-immunoreactive cells. Administration of lactoferrin had a protective effect on mouse brain cells, which manifested in a decrease in the number of TUNEL+ cells (by 77% relative to the irradiation alone) and an increase in the number of proliferating cells (from 16 to 61% relative to control animals) and immature neurons (from 14 to 22% relative to control animals) in the dentate gyrus of the hippocampus.
引用
收藏
页码：232 / 234
页数：3
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