Two new indole alkaloids isolated from a mangrove-derived fungus Colletotrichum sp. HD-1

被引：5
|
作者：
He, Dan [1 ,2 ]
Ma, Qing-Yun [2 ]
Yang, Li [2 ]
Xie, Qing-Yi [2 ]
Zhu, Hong-Juan [1 ]
Dai, Hao-Fu [2 ]
Wu, You-Gen [1 ]
Yang, Dong-Mei [1 ,3 ,4 ]
Zhao, You -Xing [2 ,4 ]
机构：
[1] Hainan Univ, Sanya Nanfan Res Inst, Sanya 572025, Peoples R China
[2] CATAS & Hainan Acad Trop Agr Resource, Inst Trop Biosci & Biotechnol, Haikou Key Lab Res & Utilizat Trop Nat Prod, Haikou 571101, Peoples R China
[3] Hainan Univ, Sch Hort, Key Lab Qual Regulat Trop Hort Crops Hainan Prov, Haikou 570228, Peoples R China
[4] Inst Trop Biosci & Biotechnol, Haikou 571101, Peoples R China
来源：
PHYTOCHEMISTRY LETTERS | 2023年 / 54卷
关键词：
Acrostichum aureum; Endophytic fungi; Colletotrichum sp; Indole alkaloids; Colletotryptin; MARINE; DERIVATIVES; FLAVONOIDS;
D O I：
10.1016/j.phytol.2023.01.015
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Two new indole alkaloids, colletotryptins G (1) and H (2), along with four known alkaloids (3-6), were isolated from an endophytic fungus Colletotrichum sp. HD-1 (Melanconiaceae) derived from the mangrove plant Acros-tichum aureum (Pteridaceae). The structures of new compounds were elucidated by comprehensive analysis of their UV, HRESIMS, and NMR data. All the isolates were evaluated for their alpha-glucosidase and acetylcholines-terase inhibitory, antibacterial, and antifungal activities. Only compound 2 showed stronger inhibitory activity against alpha-glucosidase with IC50 value of 133.4 mu M than that of the positive control acarbose (319.8 mu M).
引用
收藏
页码：81 / 85
页数：5
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