Two new indole alkaloids isolated from a mangrove-derived fungus Colletotrichum sp. HD-1

被引：5

作者：

He, Dan ^{[1
,2
]}

Ma, Qing-Yun ^{[2
]}

Yang, Li ^{[2
]}

Xie, Qing-Yi ^{[2
]}

Zhu, Hong-Juan ^{[1
]}

Dai, Hao-Fu ^{[2
]}

Wu, You-Gen ^{[1
]}

Yang, Dong-Mei ^{[1
,3
,4
]}

Zhao, You -Xing ^{[2
,4
]}

机构：

[1] Hainan Univ, Sanya Nanfan Res Inst, Sanya 572025, Peoples R China

[2] CATAS & Hainan Acad Trop Agr Resource, Inst Trop Biosci & Biotechnol, Haikou Key Lab Res & Utilizat Trop Nat Prod, Haikou 571101, Peoples R China

[3] Hainan Univ, Sch Hort, Key Lab Qual Regulat Trop Hort Crops Hainan Prov, Haikou 570228, Peoples R China

[4] Inst Trop Biosci & Biotechnol, Haikou 571101, Peoples R China

来源：

PHYTOCHEMISTRY LETTERS | 2023年 / 54卷

关键词：

Acrostichum aureum; Endophytic fungi; Colletotrichum sp; Indole alkaloids; Colletotryptin; MARINE; DERIVATIVES; FLAVONOIDS;

D O I：

10.1016/j.phytol.2023.01.015

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two new indole alkaloids, colletotryptins G (1) and H (2), along with four known alkaloids (3-6), were isolated from an endophytic fungus Colletotrichum sp. HD-1 (Melanconiaceae) derived from the mangrove plant Acros-tichum aureum (Pteridaceae). The structures of new compounds were elucidated by comprehensive analysis of their UV, HRESIMS, and NMR data. All the isolates were evaluated for their alpha-glucosidase and acetylcholines-terase inhibitory, antibacterial, and antifungal activities. Only compound 2 showed stronger inhibitory activity against alpha-glucosidase with IC50 value of 133.4 mu M than that of the positive control acarbose (319.8 mu M).

引用

页码：81 / 85

页数：5

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