Intramolecular Ring Expansion of 3-Silaazetidine with Alkynes Enabled by Pd-Catalyzed Si-C Bond Activation

被引：5

作者：

Fan, Yu ^{[1
,2
]}

Jing, Jun ^{[1
,2
]}

Tong, Ruiqi ^{[1
,2
]}

Tu, Xiaoyu ^{[1
,2
]}

Gao, Lu ^{[1
,2
]}

Wang, Wanshu ^{[1
,2
]}

Song, Zhenlei ^{[1
,2
]}

机构：

[1] Sichuan Univ, Key Lab Drug Targeting & Drug Delivery Syst, Educ Minist & Sichuan Prov, West China Sch Pharm, Chengdu 610041, Peoples R China

[2] Sichuan Univ, Sichuan Res Ctr Drug Precis Ind Technol, West China Sch Pharm, Chengdu 610041, Peoples R China

来源：

ORGANIC LETTERS | 2023年 / 25卷 / 03期

基金：

中国国家自然科学基金; 国家重点研发计划;

关键词：

SILICON ANALOG; H BONDS; SILACYCLOBUTANES; CHEMISTRY; DESYMMETRIZATION; CONSTRUCTION; SILYLATION; SILACYCLES;

D O I：

10.1021/acs.orglett.2c03698

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An intramolecular ring expansion of in situ formed 3-silaazetidine with internal alkynes has been developed via Pd catalyzed Si-C bond activation. The reaction gives rise to 6,5-and 6,6-fused bicyclic 1,3-azasilines, in which the silicon atom locates at the ring junction position.

引用

页码：455 / 460

页数：6

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