Intramolecular Ring Expansion of 3-Silaazetidine with Alkynes Enabled by Pd-Catalyzed Si-C Bond Activation

被引：5
|
作者：
Fan, Yu [1 ,2 ]
Jing, Jun [1 ,2 ]
Tong, Ruiqi [1 ,2 ]
Tu, Xiaoyu [1 ,2 ]
Gao, Lu [1 ,2 ]
Wang, Wanshu [1 ,2 ]
Song, Zhenlei [1 ,2 ]
机构：
[1] Sichuan Univ, Key Lab Drug Targeting & Drug Delivery Syst, Educ Minist & Sichuan Prov, West China Sch Pharm, Chengdu 610041, Peoples R China
[2] Sichuan Univ, Sichuan Res Ctr Drug Precis Ind Technol, West China Sch Pharm, Chengdu 610041, Peoples R China
来源：
ORGANIC LETTERS | 2023年 / 25卷 / 03期
基金：
中国国家自然科学基金; 国家重点研发计划;
关键词：
SILICON ANALOG; H BONDS; SILACYCLOBUTANES; CHEMISTRY; DESYMMETRIZATION; CONSTRUCTION; SILYLATION; SILACYCLES;
D O I：
10.1021/acs.orglett.2c03698
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An intramolecular ring expansion of in situ formed 3-silaazetidine with internal alkynes has been developed via Pd catalyzed Si-C bond activation. The reaction gives rise to 6,5-and 6,6-fused bicyclic 1,3-azasilines, in which the silicon atom locates at the ring junction position.
引用
收藏
页码：455 / 460
页数：6
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