The Mystery of Candida albicans Hyphal Morphogenesis in the Macrophage Phagolysosome

被引：1
|
作者：
Krysan, Damian J. [1 ]
机构：
[1] Univ Iowa, Carver Coll Med, Dept Pediat Mol Physiol & Biophys & Microbiol Immu, Iowa City, IA 52242 USA
来源：
INFECTION AND IMMUNITY | 2023年 / 91卷 / 05期
关键词：
Candida albicans; hyphae; macrophage;
D O I：
10.1128/iai.00104-23
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
C. albicans transitions between budding yeast and filamentous hyphal forms in a process that is tightly associated with its virulence. This transition also occurs after the fungus has been phagocytosed by macrophages. A number of somewhat discordant models have been proposed for the environmental characteristics of the phagolysosome that induce this transition. H. B. Wilson and M. C. Lorenz (Infect Immun 91:e00087-23, 2023, ) revisited these models and found that none of them explained morphogenesis in the macrophage.
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页数：3
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