The Mystery of Candida albicans Hyphal Morphogenesis in the Macrophage Phagolysosome

被引：1
|
作者：
Krysan, Damian J. [1 ]
机构：
[1] Univ Iowa, Carver Coll Med, Dept Pediat Mol Physiol & Biophys & Microbiol Immu, Iowa City, IA 52242 USA
来源：
INFECTION AND IMMUNITY | 2023年 / 91卷 / 05期
关键词：
Candida albicans; hyphae; macrophage;
D O I：
10.1128/iai.00104-23
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
C. albicans transitions between budding yeast and filamentous hyphal forms in a process that is tightly associated with its virulence. This transition also occurs after the fungus has been phagocytosed by macrophages. A number of somewhat discordant models have been proposed for the environmental characteristics of the phagolysosome that induce this transition. H. B. Wilson and M. C. Lorenz (Infect Immun 91:e00087-23, 2023, ) revisited these models and found that none of them explained morphogenesis in the macrophage.
引用
收藏
页数：3
相关论文
共 50 条
  • [21] A forkhead transcription factor is important for true hyphal as well as yeast morphogenesis in Candida albicans
    Benson, ES
    Filler, SC
    Berman, J
    [J]. EUKARYOTIC CELL, 2002, 1 (05) : 787 - 798
  • [22] Candida albicans hyphal initiation and elongation
    Lu, Yang
    Su, Chang
    Liu, Haoping
    [J]. TRENDS IN MICROBIOLOGY, 2014, 22 (12) : 707 - 714
  • [23] Article Cytochrome c regulates hyphal morphogenesis by interfering with cAMP-PKA in Candida albicans
    Zeng, Guisheng
    Xu, Xiaoli
    Kok, Yee Jiun
    Deng, Fu-Sheng
    Chow, Eve Wai Ling
    Gao, Jiaxin
    Bi, Xuezhi
    Wang, Yue
    [J]. CELL REPORTS, 2023, 42 (12):
  • [24] Enterococcus faecalis bacteriocin EntV inhibits hyphal morphogenesis, biofilm formation, and virulence of Candida albicans
    Graham, Carrie E.
    Cruz, Melissa R.
    Garsin, Danielle A.
    Lorenz, Michael C.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2017, 114 (17) : 4507 - 4512
  • [25] MORPHOLOGY AND MORPHOGENESIS OF CANDIDA ALBICANS
    MACKENZI.DW
    [J]. BRITISH MYCOLOGICAL SOCIETY TRANSACTIONS, 1965, 48 : 155 - &
  • [26] MORPHOGENESIS IN CANDIDA-ALBICANS
    ODDS, FC
    [J]. CRC CRITICAL REVIEWS IN MICROBIOLOGY, 1985, 12 (01): : 45 - 93
  • [27] Adhesion and morphogenesis in Candida albicans
    Hostetter, MK
    [J]. PEDIATRIC RESEARCH, 1996, 39 (04) : 569 - 573
  • [28] Regulation of the hyphal transcription program in Candida albicans
    Raniga, PP
    Shrivastava, M
    Liu, HP
    [J]. YEAST, 2003, 20 : S78 - S78
  • [29] Propranolol inhibits hyphal development in Candida albicans
    Baker, CA
    Desrosiers, K
    Dolan, JW
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2002, 46 (11) : 3617 - 3620
  • [30] Functional Dichotomy for a Hyphal Repressor in Candida albicans
    Mao, Yinhe
    Solis, Norma V. V.
    Filler, Scott G. G.
    Mitchell, Aaron P. P.
    [J]. MBIO, 2023, 14 (02):
12345