Molecular complexity of intraductal carcinoma of the prostate

被引：3
|
作者：
Zhu, Sha [1 ]
Xu, Nanwei [1 ]
Zeng, Hao [1 ,2 ]
机构：
[1] Sichuan Univ, West China Hosp, Inst Urol, Dept Urol, Chengdu, Peoples R China
[2] Sichuan Univ, West China Hosp, Inst Urol, Dept Urol, Chengdu 610041, Peoples R China
来源：
CANCER MEDICINE | 2024年 / 13卷 / 02期
关键词：
DNA damage and repair; Intraductal carcinoma of the prostate; MED12; molecular characteristics; MYC; NCOR2; prostate acinar adenocarcinoma; PTEN; RB1; SChLAP1; targeted therapy; TMPRSS2-ERG fusion; TP53; GLEASON PATTERN 4; TMPRSS2-ERG GENE FUSION; PTEN GENOMIC DELETION; PSA RECURRENCE; INTRAEPITHELIAL NEOPLASIA; INVASIVE ADENOCARCINOMA; RADICAL PROSTATECTOMY; HISTOLOGIC FEATURES; ANALYTIC VALIDATION; MED12; MUTATIONS;
D O I：
10.1002/cam4.6939
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Intraductal carcinoma of the prostate (IDC-P) is an aggressive subtype of prostate cancer characterized by the growth of tumor cells within the prostate ducts. It is often found alongside invasive carcinoma and is associated with poor prognosis. Understanding the molecular mechanisms driving IDC-P is crucial for improved diagnosis, prognosis, and treatment strategies. This review summarizes the molecular characteristics of IDC-P and their prognostic indications, comparing them to conventional prostate acinar adenocarcinoma, to gain insights into its unique behavior and identify potential therapeutic targets.
引用
收藏
页数：10
相关论文
共 50 条
  • [41] The highs and lows of grading intraductal carcinoma of the prostate
    Mcdonald, Jodie ai ling
    O'Brien, Jonathan
    Kelly, Brian
    Murphy, Declan
    Lawrentschuk, Nathan
    Eapen, Renu
    Mitchell, Catherine
    JOURNAL OF CLINICAL PATHOLOGY, 2024, 77 (12) : 812 - 814
  • [42] Mass-Forming Intraductal Carcinoma of the Prostate
    Fine, S. W.
    Gopalan, A.
    Tickoo, S. K.
    Reuter, V. E.
    LABORATORY INVESTIGATION, 2009, 89 : 168A - 168A
  • [43] Intraductal carcinoma of the prostate: A comprehensive and updated review
    Tsuzuki, Toyonori
    INTERNATIONAL JOURNAL OF UROLOGY, 2015, 22 (02) : 140 - 145
  • [44] Intraductal Carcinoma of The Prostate: Is There a Need for Genetic Screening?
    Coyne, S. O'Grady
    Haroon, U.
    O'Neill, M.
    Gullman, C.
    Cheema, I.
    Forde, J.
    Mc Lornan, L.
    IRISH JOURNAL OF MEDICAL SCIENCE, 2018, 187 : S142 - S142
  • [45] Comedonecrosis Revisited: Assocations with Intraductal Carcinoma of the Prostate
    Fine, S. W.
    Udo, K.
    Al-Ahmadie, H. A.
    Chen, Y-B
    Gopalan, A.
    Tickoo, S. K.
    Reuter, V. E.
    LABORATORY INVESTIGATION, 2011, 91 : 192A - 192A
  • [46] Transcriptomic Features of Cribriform and Intraductal Carcinoma of the Prostate
    Lone, Z.
    Benidir, T.
    Rainey, M.
    Nair, M.
    Davicioni, E.
    Gibb, E.
    Williamson, S.
    Nguyen, J. K.
    Gupta, S.
    Ornstein, M. C.
    Ciezki, J. P.
    Stephans, K. L.
    Tendulkar, R. D.
    Weight, C.
    Klein, E. A.
    Mian, O. Y.
    INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2022, 114 (03): : S170 - S170
  • [47] Current Understanding and Management of Intraductal Carcinoma of the Prostate
    Bryden Considine
    Adebowale Adeniran
    Michael E. Hurwitz
    Current Oncology Reports, 2021, 23
  • [48] Intraductal carcinoma of the prostate: Is there a need for a genetic screening?
    Coyne, S. O'Grady
    Haroon, U. M.
    O'Neill, M.
    Gullmann, C.
    Cheema, I. A.
    Forde, J. C.
    McLornan, L.
    BJU INTERNATIONAL, 2018, 122 : 38 - 39
  • [49] Intraductal Carcinoma of the Prostate: A Guide for the Practicing Pathologist
    Varma, Murali
    ADVANCES IN ANATOMIC PATHOLOGY, 2021, 28 (04) : 276 - 287
  • [50] Current Understanding and Management of Intraductal Carcinoma of the Prostate
    Considine, Bryden
    Adeniran, Adebowale
    Hurwitz, Michael E.
    CURRENT ONCOLOGY REPORTS, 2021, 23 (09)
12345