Molecular complexity of intraductal carcinoma of the prostate

被引：3
|
作者：
Zhu, Sha [1 ]
Xu, Nanwei [1 ]
Zeng, Hao [1 ,2 ]
机构：
[1] Sichuan Univ, West China Hosp, Inst Urol, Dept Urol, Chengdu, Peoples R China
[2] Sichuan Univ, West China Hosp, Inst Urol, Dept Urol, Chengdu 610041, Peoples R China
来源：
CANCER MEDICINE | 2024年 / 13卷 / 02期
关键词：
DNA damage and repair; Intraductal carcinoma of the prostate; MED12; molecular characteristics; MYC; NCOR2; prostate acinar adenocarcinoma; PTEN; RB1; SChLAP1; targeted therapy; TMPRSS2-ERG fusion; TP53; GLEASON PATTERN 4; TMPRSS2-ERG GENE FUSION; PTEN GENOMIC DELETION; PSA RECURRENCE; INTRAEPITHELIAL NEOPLASIA; INVASIVE ADENOCARCINOMA; RADICAL PROSTATECTOMY; HISTOLOGIC FEATURES; ANALYTIC VALIDATION; MED12; MUTATIONS;
D O I：
10.1002/cam4.6939
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Intraductal carcinoma of the prostate (IDC-P) is an aggressive subtype of prostate cancer characterized by the growth of tumor cells within the prostate ducts. It is often found alongside invasive carcinoma and is associated with poor prognosis. Understanding the molecular mechanisms driving IDC-P is crucial for improved diagnosis, prognosis, and treatment strategies. This review summarizes the molecular characteristics of IDC-P and their prognostic indications, comparing them to conventional prostate acinar adenocarcinoma, to gain insights into its unique behavior and identify potential therapeutic targets.
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页数：10
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