Exploring the significance of lipids in Alzheimer's disease and the potential of extracellular vesicles

被引：3
|
作者：
Su, Huaqi [1 ,2 ,5 ]
Masters, Colin L. [1 ]
Bush, Ashley I. [1 ]
Barnham, Kevin J. [1 ]
Reid, Gavin E. [2 ,3 ]
Vella, Laura J. [1 ,4 ,5 ]
机构：
[1] Univ Melbourne, The Florey, Parkville, Vic, Australia
[2] Univ Melbourne, Sch Chem, Bio21 Mol Sci & Biotechnol Inst, Parkville, Vic, Australia
[3] Univ Melbourne, Dept Biochem & Pharmacol, Parkville, Vic, Australia
[4] Univ Melbourne, Royal Melbourne Hosp, Dept Surg, Parkville, Vic, Australia
[5] 30 Royal Parade, Melbourne, Vic 3052, Australia
来源：
PROTEOMICS | 2024年 / 24卷 / 11期
基金：
英国医学研究理事会;
关键词：
Alzheimer's disease; blood; central nervous system; lipids; small extracellular vesicles; MILD COGNITIVE IMPAIRMENT; AMYLOID-BETA-PEPTIDE; ETHANOLAMINE PLASMALOGEN DEFICIENCY; CEREBROSPINAL-FLUID; NATIONAL INSTITUTE; OXIDATIVE STRESS; ASSOCIATION WORKGROUPS; DIAGNOSTIC GUIDELINES; PRECURSOR PROTEIN; MASS-SPECTROMETRY;
D O I：
10.1002/pmic.202300063
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Lipids play a significant role in maintaining central nervous system (CNS) structure and function, and the dysregulation of lipid metabolism is known to occur in many neurological disorders, including Alzheimer's disease. Here we review what is currently known about lipid dyshomeostasis in Alzheimer's disease. We propose that small extracellular vesicle (sEV) lipids may provide insight into the pathophysiology and progression of Alzheimer's disease. This stems from the recognition that sEV likely contributes to disease pathogenesis, but also an understanding that sEV can serve as a source of potential biomarkers. While the protein and RNA content of sEV in the CNS diseases have been studied extensively, our understanding of the lipidome of sEV in the CNS is still in its infancy.
引用
收藏
页数：21
相关论文
共 50 条
  • [31] Extracellular Vesicles as a Neprilysin Delivery System Memory Improvement in Alzheimer's Disease
    Izadpanah, Mehrnaz
    Dargahi, Leila
    Ai, Jafar
    Taei, Afsaneh Asgari
    Barough, Somayeh Ebrahimi
    Mowla, Seyed Javad
    TavoosiDana, Gholamreza
    Farahmandfar, Maryam
    IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH, 2020, 19 (02): : 45 - 60
  • [32] Modulation of the presynaptic local translatome by astrocytic extracellular vesicles in Alzheimer's Disease
    de la Cruz, A.
    Gamarra, M.
    Baleriola, J.
    GLIA, 2021, 69 : E290 - E291
  • [33] Neuronally derived extracellular vesicles: an emerging tool for understanding Alzheimer's disease
    Watson, Luke S.
    Hamlett, Eric D.
    Stone, Tyler D.
    Sims-Robinson, Catrina
    MOLECULAR NEURODEGENERATION, 2019, 14
  • [34] Extracellular Vesicles in Alzheimer's Disease: Friends or Foes? Focus on Aβ-Vesicle Interaction
    Joshi, Pooja
    Benussi, Luisa
    Furlan, Roberto
    Ghidoni, Roberta
    Verderio, Claudia
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2015, 16 (03): : 4800 - 4813
  • [35] Sphingolipid-Enriched Extracellular Vesicles and Alzheimer's Disease: A Decade of Research
    Dinkins, Michael B.
    Wang, Guanghu
    Bieberich, Erhard
    JOURNAL OF ALZHEIMERS DISEASE, 2017, 60 (03) : 757 - 768
  • [36] Microfluidics in neural extracellular vesicles characterization for early Alzheimer's disease diagnosis
    Zare, Hossein
    Kasdorf, Michelle M.
    Nik, Amirala Bakhshian
    MOLECULAR AND CELLULAR NEUROSCIENCE, 2025, 132
  • [37] Tau filaments are tethered within brain extracellular vesicles in Alzheimer's disease
    Fowler, Stephanie L.
    Behr, Tiana S.
    Turkes, Emir
    O'Brien, Darragh P.
    Cauhy, Paula Maglio
    Rawlinson, Isadora
    Edmonds, Marisa
    Foiani, Martha S.
    Schaler, Ari
    Crowley, Gerard
    Bez, Sumi
    Ficulle, Elena
    Tsefou, Eliona
    Fischer, Roman
    Geary, Beth
    Gaur, Pallavi
    Miller, Chelsea
    D'Acunzo, Pasquale
    Levy, Efrat
    Duff, Karen E.
    Ryskeldi-Falcon, Benjamin
    NATURE NEUROSCIENCE, 2025, 28 (01) : 40 - 48
  • [38] Lipids in Alzheimer's disease
    Duflot, Valerie
    OCL-OILSEEDS AND FATS CROPS AND LIPIDS, 2018, 25 (04)
  • [39] Characterization of brain-derived extracellular vesicle lipids in Alzheimer's disease
    Su, Huaqi
    Rustam, Yepy H.
    Masters, Colin L.
    Makalic, Enes
    McLean, Catriona A.
    Hill, Andrew F.
    Barnham, Kevin J.
    Reid, Gavin E.
    Vella, Laura J.
    JOURNAL OF EXTRACELLULAR VESICLES, 2021, 10 (07)
  • [40] Lipids and Alzheimer's disease
    Garner, Brett
    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 2010, 1801 (08): : 747 - 749
12345