Extracellular Vesicles in Alzheimer's Disease: Friends or Foes? Focus on Aβ-Vesicle Interaction

被引：72
|
作者：
Joshi, Pooja [1 ]
Benussi, Luisa [2 ]
Furlan, Roberto [3 ]
Ghidoni, Roberta [2 ]
Verderio, Claudia [1 ,4 ]
机构：
[1] CNR, Inst Neurosci, I-20129 Milan, Italy
[2] IRCCS Ist Ctr San Giovanni di Dio Fatebenefratell, Mol Markers Lab, I-25125 Brescia, Italy
[3] Ist Sci San Raffaele, Div Neurosci, Inst Expt Neurol, I-20132 Milan, Italy
[4] IRCCS Humanitas, I-20089 Rozzano, Italy
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2015年 / 16卷 / 03期
关键词：
PRION-LIKE TRANSMISSION; AMYLOID-BETA; CEREBROSPINAL-FLUID; IN-VIVO; NEURODEGENERATIVE DISEASES; SYNAPTIC PLASTICITY; TERMINAL FRAGMENTS; PROTEIN; EXOSOMES; TAU;
D O I：
10.3390/ijms16034800
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The intercellular transfer of amyloid-beta (A beta) and tau proteins has received increasing attention in Alzheimer's disease (AD). Among other transfer modes, A beta and tau dissemination has been suggested to occur through release of Extracellular Vesicles (EVs), which may facilitate delivery of pathogenic proteins over large distances. Recent evidence indicates that EVs carry on their surface, specific molecules which bind to extracellular A beta, opening the possibility that EVs may also influence A beta assembly and synaptotoxicity. In this review we focus on studies which investigated the impact of EVs in A beta-mediated neurodegeneration and showed either detrimental or protective role for EVs in the pathology.
引用
收藏
页码：4800 / 4813
页数：14
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