The determinants of fasting and post-load non-esterified fatty acids in older adults: The cardiovascular health study

被引:0
|
作者
Bene-Alhasan, Yakubu [1 ,2 ]
Siscovick, David S. [3 ]
Ix, Joachim H. [4 ,5 ]
Kizer, Jorge R. [6 ,7 ]
Tracy, Russell [8 ]
Djousse, Luc [9 ,10 ]
Mukamal, Kenneth J. [2 ,11 ]
机构
[1] Medstar Union Mem Hosp, Dept Med, Baltimore, MD USA
[2] Beth Israel Deaconess Med Ctr, Harvard Med Sch, Dept Med, Boston, MA USA
[3] New York Acad Med, New York, NY USA
[4] Univ Calif San Diego, Dept Med, San Diego, CA USA
[5] Vet Affairs San Diego Healthcare Syst, San Diego, CA USA
[6] Univ Calif San Francisco, Dept Med, Cardiol Sect, San Francisco Vet Affairs Hlth Care Syst, San Francisco, CA USA
[7] Univ Calif San Francisco, Dept Epidemiol & Biostat, Cardiol Sect, San Francisco Vet Affairs Hlth Care Syst, San Francisco, CA USA
[8] Univ Vermont, Larner Coll Med, Dept Pathol & Lab Med, Colchester, VT USA
[9] Brigham & Womens Hosp, Dept Med, Boston, MA 02115 USA
[10] Harvard Med Sch, Boston, MA 02115 USA
[11] 1309 Beacon St,2nd Floor, Brookline, MA 02446 USA
来源
METABOLISM OPEN | 2023年 / 20卷
关键词
Epidemiology; Fatty acid; Lifestyle; Non-esterified fatty acid; Nutrition; TOTAL-ENERGY-INTAKE; BINDING PROTEIN 4; INSULIN-RESISTANCE; GLUCOSE-TOLERANCE; HEART-FAILURE; CAFFEINE; RISK; COFFEE; INGESTION; RESPONSES;
D O I
10.1016/j.metop.2023.100261
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Aim: Non-esterified fatty acids (NEFA) are potential targets for prevention of key cardiometabolic diseases of aging, but their population-level correlates remain uncertain. We sought to identify modifiable factors associated with fasting and post-load NEFA levels in older adults. Methods: We used linear regression to determine the cross-sectional associations of demographic, anthropometric, and lifestyle characteristics and medication use with serum fasting and post-load NEFA concentrations amongst community-dwelling older adults enrolled in the Cardiovascular Health Study (n = 1924). Results: Fasting NEFA levels generally demonstrated a broader set of determinants, while post-load NEFA were more consistently associated with metabolic factors. Waist circumference and weight were associated with higher fasting and post-load NEFA. Cigarette smoking and caffeine intake were associated with lower levels of both species, and moderate alcohol intake was associated with higher fasting levels whereas greater consumption was associated with lower post-load levels. Unique factors associated with higher fasting NEFA included female sex, higher age, loop and thiazide diuretic use and calcium intake, while factors associated with lower fasting levels included higher educational attainment, beta-blocker use, and protein intake. Hours spent sleeping during the daytime were associated with higher post-load NEFA, while DASH score was associated with lower levels. Conclusion: Fasting and post-load NEFA have both common and unique modifiable risk factors, including sociodemographics, anthropometric, medications, and diet. Post-load NEFA were particularly sensitive to metabolic factors, while a broader range of determinants were associated with fasting levels. These factors warrant study as targets for lowering levels of NEFA in older adults.
引用
收藏
页数:7
相关论文
共 50 条
  • [41] Plasma Phospholipid Very Long Chain Saturated Fatty Acids and Healthy Aging in Older Adults: The Cardiovascular Health Study
    Lemaitre, Rozenn N.
    Biggs, Mary L.
    McKnight, Barbara
    Lai, Heidi T.
    Song, Xiaoling
    King, Irena B.
    Psaty, Bruce M.
    Siscovick, David S.
    Mozaffarian, Dariush
    CIRCULATION, 2018, 137
  • [42] Lactation intensity and fasting plasma lipids, lipoproteins, non-esterified free fatty acids, leptin and adiponectin in postpartum women with recent gestational diabetes mellitus: The SWIFT cohort
    Gunderson, Erica P.
    Kim, Catherine
    Quesenberry, Charles P.
    Marcovina, Santica
    Walton, David
    Azevedo, Robert A.
    Fox, Gary
    Elmasian, Cathie
    Young, Stephen
    Salvador, Nora
    Lum, Michael
    Crites, Yvonne
    Lo, Joan C.
    Ning, Xian
    Dewey, Kathryn G.
    METABOLISM-CLINICAL AND EXPERIMENTAL, 2014, 63 (07): : 941 - 950
  • [43] Non-EsterifiedFatty Acids and Risks of Frailty, Disability, and Mobility Limitation in Older Adults: The Cardiovascular Health Study
    Ahiawodzi, Peter
    Djousse, Luc
    Ix, Joachim H.
    Kizer, Jorge R.
    Tracy, Russell P.
    Arnold, Alice
    Newman, Anne
    Mukamal, Kenneth J.
    JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 2020, 68 (12) : 2890 - 2897
  • [44] Higher circulating levels of non-esterified fatty acids are associated with faster kidney function decline in post-menopausal women with type 2 diabetes: a pilot prospective study
    Mantovani, Alessandro
    Csermely, Alessandro
    Cappelli, Davide
    Taverna, Antonio
    Sani, Elena
    Shtembari, Emigela
    Pagani, Micol
    Targher, Giovanni
    ACTA DIABETOLOGICA, 2024, 61 (03) : 281 - 288
  • [45] IN VITRO PRODUCTION OF NON-ESTERIFIED FATTY ACIDS DURING INCUBATION OF VARIOUS TYPES OF ADIPOSE TISSUE FROM FASTING AND FED RATS .1. MOBILIZATION OF FATTY ACIDS FROM EPIDIDYMAL, PERINEPHRIC, AND SUBCUTANEOUS ADIPOSE TISSUE
    MUNKNER, C
    SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION, 1963, 15 (01): : 83 - &
  • [46] Higher circulating levels of non-esterified fatty acids are associated with faster kidney function decline in post-menopausal women with type 2 diabetes: a pilot prospective study
    Alessandro Mantovani
    Alessandro Csermely
    Davide Cappelli
    Antonio Taverna
    Elena Sani
    Emigela Shtembari
    Micol Pagani
    Giovanni Targher
    Acta Diabetologica, 2024, 61 : 281 - 288
  • [47] Plasma-Free Fatty Acids, Fatty Acid-Binding Protein 4, and Mortality in Older Adults (from the Cardiovascular Health Study)
    Miedema, Michael D.
    Maziarz, Marlena
    Biggs, Mary L.
    Zieman, Susan J.
    Kizer, Jorge R.
    Ix, Joachim H.
    Mozaffarian, Dariush
    Tracy, Russell P.
    Psaty, Bruce M.
    Siscovick, David S.
    Mukamal, Kenneth J.
    Djousse, Luc
    AMERICAN JOURNAL OF CARDIOLOGY, 2014, 114 (06): : 843 - 848
  • [48] Alterations of Lipoprotein fluidity by non-esterified fatty acids known to affect cholesteryl ester transfer protein activity - An electron spin resonance study
    Foucher, C
    Lagrost, L
    Maupoil, V
    LeMeste, M
    Rochette, L
    Gambert, P
    EUROPEAN JOURNAL OF BIOCHEMISTRY, 1996, 236 (02): : 436 - 442
  • [49] Plasma phospholipid trans-fatty acids and fatal ischemic heart disease in older adults. The Cardiovascular Health Study
    Lemaitre, RN
    King, IB
    Mozaffarian, D
    Kuller, LH
    Tracy, RP
    Sotoodehnia, N
    Siscovick, DS
    CIRCULATION, 2005, 111 (14) : E249 - E249
  • [50] Plasma phospholipid very-long-chain saturated fatty acids and incident diabetes in older adults: the Cardiovascular Health Study
    Lemaitre, Rozenn N.
    Fretts, Amanda M.
    Sitlani, Colleen M.
    Biggs, Mary L.
    Mukamal, Kenneth
    King, Irena B.
    Song, Xiaoling
    Djousse, Luc
    Siscovick, David S.
    McKnight, Barbara
    Sotoodehnia, Nona
    Kizer, Jorge R.
    Mozaffarian, Dariush
    AMERICAN JOURNAL OF CLINICAL NUTRITION, 2015, 101 (05): : 1047 - 1054