The determinants of fasting and post-load non-esterified fatty acids in older adults: The cardiovascular health study

被引:0
|
作者
Bene-Alhasan, Yakubu [1 ,2 ]
Siscovick, David S. [3 ]
Ix, Joachim H. [4 ,5 ]
Kizer, Jorge R. [6 ,7 ]
Tracy, Russell [8 ]
Djousse, Luc [9 ,10 ]
Mukamal, Kenneth J. [2 ,11 ]
机构
[1] Medstar Union Mem Hosp, Dept Med, Baltimore, MD USA
[2] Beth Israel Deaconess Med Ctr, Harvard Med Sch, Dept Med, Boston, MA USA
[3] New York Acad Med, New York, NY USA
[4] Univ Calif San Diego, Dept Med, San Diego, CA USA
[5] Vet Affairs San Diego Healthcare Syst, San Diego, CA USA
[6] Univ Calif San Francisco, Dept Med, Cardiol Sect, San Francisco Vet Affairs Hlth Care Syst, San Francisco, CA USA
[7] Univ Calif San Francisco, Dept Epidemiol & Biostat, Cardiol Sect, San Francisco Vet Affairs Hlth Care Syst, San Francisco, CA USA
[8] Univ Vermont, Larner Coll Med, Dept Pathol & Lab Med, Colchester, VT USA
[9] Brigham & Womens Hosp, Dept Med, Boston, MA 02115 USA
[10] Harvard Med Sch, Boston, MA 02115 USA
[11] 1309 Beacon St,2nd Floor, Brookline, MA 02446 USA
来源
METABOLISM OPEN | 2023年 / 20卷
关键词
Epidemiology; Fatty acid; Lifestyle; Non-esterified fatty acid; Nutrition; TOTAL-ENERGY-INTAKE; BINDING PROTEIN 4; INSULIN-RESISTANCE; GLUCOSE-TOLERANCE; HEART-FAILURE; CAFFEINE; RISK; COFFEE; INGESTION; RESPONSES;
D O I
10.1016/j.metop.2023.100261
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Aim: Non-esterified fatty acids (NEFA) are potential targets for prevention of key cardiometabolic diseases of aging, but their population-level correlates remain uncertain. We sought to identify modifiable factors associated with fasting and post-load NEFA levels in older adults. Methods: We used linear regression to determine the cross-sectional associations of demographic, anthropometric, and lifestyle characteristics and medication use with serum fasting and post-load NEFA concentrations amongst community-dwelling older adults enrolled in the Cardiovascular Health Study (n = 1924). Results: Fasting NEFA levels generally demonstrated a broader set of determinants, while post-load NEFA were more consistently associated with metabolic factors. Waist circumference and weight were associated with higher fasting and post-load NEFA. Cigarette smoking and caffeine intake were associated with lower levels of both species, and moderate alcohol intake was associated with higher fasting levels whereas greater consumption was associated with lower post-load levels. Unique factors associated with higher fasting NEFA included female sex, higher age, loop and thiazide diuretic use and calcium intake, while factors associated with lower fasting levels included higher educational attainment, beta-blocker use, and protein intake. Hours spent sleeping during the daytime were associated with higher post-load NEFA, while DASH score was associated with lower levels. Conclusion: Fasting and post-load NEFA have both common and unique modifiable risk factors, including sociodemographics, anthropometric, medications, and diet. Post-load NEFA were particularly sensitive to metabolic factors, while a broader range of determinants were associated with fasting levels. These factors warrant study as targets for lowering levels of NEFA in older adults.
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页数:7
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