Relay Organophotoredox/N-Heterocyclic Carbene Catalysis-Enabled Asymmetric Synthesis of Dibenzoxazepine-Fused Pyrrolidinones

被引：6

作者：

Hussain, Yaseen ^{[1
]}

Sharma, Deepak ^{[1
]}

Tamanna ^{[1
]}

Chauhan, Pankaj ^{[1
]}

机构：

[1] Indian Inst Technol Jammu, Dept Chem, Jagti 181221, Jammu & Kashmir, India

来源：

ORGANIC LETTERS | 2023年 / 25卷 / 14期

关键词：

PHOTOREDOX CATALYSIS; COOPERATIVE PHOTOREDOX; TERTIARY-AMINES; DUAL CATALYSIS; ALDEHYDES; UMPOLUNG; KETONES; ACID;

D O I：

10.1021/acs.orglett.3c00685

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An unprecedented highly stereoselective synthesis of pyrrolo[1,2-d][1,4]oxazepin-3(2H)-ones has been accomplished via photoredox/N-heterocyclic carbene (NHC) relay catalysis. A wide range of substituted dibenzoxazepines and aryl/hetereoaryl enals were well accommodated under the organic photoredox catalysis- promoted amine oxidation to generate the imines, followed by a NHC-catalyzed [3 + 2] annulation reaction to achieve excellent diastereo- and enantioselectivities of the dibenzoxazepine-fused pyrrolidinones.

引用

页码：2520 / 2524

页数：5

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