A low-volume flow electrochemical microreactor for rapid and automated process optimization

被引：2

作者：

Rial-Rodriguez, Eduardo ^{[1
,2
]}

Wagner, Johannes F. ^{[1
,2
]}

Eggenweiler, Hans-Michael ^{[3
]}

Fuchss, Thomas ^{[3
]}

Sommer, Alena ^{[3
]}

Kappe, C. Oliver ^{[1
,2
]}

Williams, Jason D. ^{[1
,2
]}

Cantillo, David ^{[1
,2
]}

机构：

[1] Karl Franzens Univ Graz, Inst Chem, NAWI Graz, Heinrichstr 28, A-8010 Graz, Austria

[2] Res Ctr Pharmaceut Engn GmbH RCPE, Ctr Continuous Flow Synth & Proc CCFLOW, Inffeldgasse 13, A-8010 Graz, Austria

[3] Merck Healthcare KGaA, Med Chem & Drug Design, Frankfurter Str 250, D-64293 Darmstadt, Germany

来源：

REACTION CHEMISTRY & ENGINEERING | 2023年 / 9卷 / 01期

关键词：

ELECTROORGANIC SYNTHESIS; ALCOHOLS;

D O I：

10.1039/d3re00586k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Electrochemical reactions under constant current can be completed within very short periods of time in microliter-volume cells, as electrolysis time is proportional to the quantity of material processed. A flexible electrochemical microreactor with 17 mu L volume has been designed and constructed, which enables reactions to be performed in as little as 7.3 s residence time using standard, commercially available electrodes. By utilizing automation and statistical analysis, the reaction design space was explored for three model reactions in 2-3 hours, consuming only 30-300 mg of material for 42 experiments. A microliter-volume flow electrolysis cell, combined with a fully automated platform which includes parameters variation and sample collection, enables high-throughput screening of electrolysis conditions within 2-3 hours.

引用

页码：31 / 36

页数：6

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