A low-volume flow electrochemical microreactor for rapid and automated process optimization

被引：2
|
作者：
Rial-Rodriguez, Eduardo [1 ,2 ]
Wagner, Johannes F. [1 ,2 ]
Eggenweiler, Hans-Michael [3 ]
Fuchss, Thomas [3 ]
Sommer, Alena [3 ]
Kappe, C. Oliver [1 ,2 ]
Williams, Jason D. [1 ,2 ]
Cantillo, David [1 ,2 ]
机构：
[1] Karl Franzens Univ Graz, Inst Chem, NAWI Graz, Heinrichstr 28, A-8010 Graz, Austria
[2] Res Ctr Pharmaceut Engn GmbH RCPE, Ctr Continuous Flow Synth & Proc CCFLOW, Inffeldgasse 13, A-8010 Graz, Austria
[3] Merck Healthcare KGaA, Med Chem & Drug Design, Frankfurter Str 250, D-64293 Darmstadt, Germany
来源：
REACTION CHEMISTRY & ENGINEERING | 2023年 / 9卷 / 01期
关键词：
ELECTROORGANIC SYNTHESIS; ALCOHOLS;
D O I：
10.1039/d3re00586k
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Electrochemical reactions under constant current can be completed within very short periods of time in microliter-volume cells, as electrolysis time is proportional to the quantity of material processed. A flexible electrochemical microreactor with 17 mu L volume has been designed and constructed, which enables reactions to be performed in as little as 7.3 s residence time using standard, commercially available electrodes. By utilizing automation and statistical analysis, the reaction design space was explored for three model reactions in 2-3 hours, consuming only 30-300 mg of material for 42 experiments. A microliter-volume flow electrolysis cell, combined with a fully automated platform which includes parameters variation and sample collection, enables high-throughput screening of electrolysis conditions within 2-3 hours.
引用
收藏
页码：31 / 36
页数：6
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