Lung Dual-Energy CT Perfusion Blood Volume as a Marker of Severity in Chronic Thromboembolic Pulmonary Hypertension

被引：5
|
作者：
Si-Mohamed, Salim A. [1 ,2 ]
Zumbihl, Lea [1 ]
Turquier, Segolene [3 ,4 ,5 ]
Boccalini, Sara [1 ,2 ]
Mornex, Jean-Francois [3 ,4 ,5 ]
Douek, Philippe [1 ,2 ]
Cottin, Vincent [3 ,4 ,5 ]
Boussel, Loic [1 ,2 ]
机构：
[1] Louis Pradel Hosp, Radiol Dept, 59 Blvd Pinel, F-69500 Bron, France
[2] Univ Lyon, Univ Claude Bernard Lyon 1, INSA Lyon, UJM St Etienne,CNRS,Inserm,CREATIS,UMR 5220,U1206, F-69621 Lyon, France
[3] Louis Pradel Hosp, Natl Reference Ctr Rare Pulm Dis, Hosp Civils Lyon, F-69677 Lyon, France
[4] Claude Bernard Univ Lyon, INRAE, UMR 754, F-69007 Lyon, France
[5] ERN LUNG, F-69500 Bron, France
来源：
DIAGNOSTICS | 2023年 / 13卷 / 04期
关键词：
tomography; X-ray computed; methods; lung; perfusion; comparative study; COMPUTED-TOMOGRAPHY; ANGIOGRAPHY;
D O I：
10.3390/diagnostics13040769
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
In chronic thromboembolic pulmonary hypertension (CTEPH), assessment of severity requires right heart catheterization (RHC) through cardiac index (CI). Previous studies have shown that dual-energy CT allows a quantitative assessment of the lung perfusion blood volume (PBV). Therefore, the objective was to evaluate the quantitative PBV as a marker of severity in CTEPH. In the present study, thirty-three patients with CTEPH (22 women, 68.2 +/- 14.8 years) were included from May 2017 to September 2021. Mean quantitative PBV was 7.6% +/- 3.1 and correlated with CI (r = 0.519, p = 0.002). Mean qualitative PBV was 41.1 +/- 13.4 and did not correlate with CI. Quantitative PBV AUC values were 0.795 (95% CI: 0.637-0.953, p = 0.013) for a CI >= 2 L/min/m(2) and 0.752 (95% CI: 0.575-0.929, p = 0.020) for a CI >= 2.5 L/min/m(2). In conclusion, quantitative lung PBV outperformed qualitative PBV for its correlation with the cardiac index and may be used as a non-invasive marker of severity in CTPEH patients.
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页数：10
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