Lung Dual-Energy CT Perfusion Blood Volume as a Marker of Severity in Chronic Thromboembolic Pulmonary Hypertension

In chronic thromboembolic pulmonary hypertension (CTEPH), assessment of severity requires right heart catheterization (RHC) through cardiac index (CI). Previous studies have shown that dual-energy CT allows a quantitative assessment of the lung perfusion blood volume (PBV). Therefore, the objective was to evaluate the quantitative PBV as a marker of severity in CTEPH. In the present study, thirty-three patients with CTEPH (22 women, 68.2 +/- 14.8 years) were included from May 2017 to September 2021. Mean quantitative PBV was 7.6% +/- 3.1 and correlated with CI (r = 0.519, p = 0.002). Mean qualitative PBV was 41.1 +/- 13.4 and did not correlate with CI. Quantitative PBV AUC values were 0.795 (95% CI: 0.637-0.953, p = 0.013) for a CI >= 2 L/min/m(2) and 0.752 (95% CI: 0.575-0.929, p = 0.020) for a CI >= 2.5 L/min/m(2). In conclusion, quantitative lung PBV outperformed qualitative PBV for its correlation with the cardiac index and may be used as a non-invasive marker of severity in CTPEH patients.