Lurasidone in first-episode psychosis with predominant depressive symptoms: a case report

被引：4

作者：

Ricci, Valerio ^{[1
,3
]}

Di Salvo, Gabriele ^{[2
]}

Maina, Giuseppe ^{[2
]}

机构：

[1] San Luigi Gonzaga Univ Hosp, Dept Psychiat, Orbassano, Regione Gonzole, Italy

[2] Univ Turin, Rita Levi Montalcini Dept Neurosci, Turin, Italy

[3] San Luigi Gonzaga Univ Hosp, Dept Psychiat, Reg Gonzole 10, I-10043 Turin, Italy

来源：

INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY | 2023年 / 38卷 / 04期

关键词：

depression; first-episode psychosis; lurasidone; negative symptoms; psychotic symptoms; schizophrenia; SCHIZOPHRENIA; 5-HT7;

D O I：

10.1097/YIC.0000000000000465

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Lurasidone is an atypical antipsychotic approved for the treatment of schizophrenia and bipolar depression. It seems to have an antidepressant effect due to 5-HT7 as well as 5-HT2A and 5-HT1a receptor affinity. Here we present a case of a 19-year-old male patient with first-episode psychosis (FEP) and predominant depressive symptoms. Remarkable clinical and functional improvement was observed 3 months after the beginning of lurasidone treatment. The patient's depressive symptoms disappear with a dramatic reduction of psychotic ones, with good tolerance of the drug and without adverse effects. Lurasidone seems to be a promising treatment option for FEP with predominant depressive symptoms.

引用

页码：275 / 280

页数：6

共 50 条

[41] Religiousness in First-Episode Psychosis
Hanevik, Hilde
Hestad, Knut A.
Lien, Lars
Joa, Inge
Larsen, Tor Ketil
Danbolt, Lars Johan
ARCHIVE FOR THE PSYCHOLOGY OF RELIGION-ARCHIV FUR RELIGIONSPSYCHOLOGIE, 2017, 39 (02): : 139 - 164
[42] Pharmacotherapy of first-episode psychosis
Lambert, M
Conus, P
Lambert, T
McGorry, PD
EXPERT OPINION ON PHARMACOTHERAPY, 2003, 4 (05) : 717 - 750
[43] Therapeutic alliance with case managers in first-episode psychosis
Chua, Yi Chian
Tang, Charmaine
Abdin, Edimansyah
Vaingankar, Janhavi Ajit
Shahwan, Shazana
Cetty, Laxman
Yong, Yee Huei
Hon, Charlene
Ang, Suying
Verma, Swapna
Subramaniam, Mythily
ASIAN JOURNAL OF PSYCHIATRY, 2022, 72
[44] Neurocognitive function in first episode psychosis: Relationship with depressive symptoms
McCaul, R
Barrett, SL
Anderson, R
Rushe, TM
Cooper, SJ
Mulholland, C
SCHIZOPHRENIA BULLETIN, 2005, 31 (02) : 335 - 335
[45] First episode psychosis: the depressive symptoms and suicidal behaviour that follow
Mesquita, B. L. B.
Ribeirinho Soares, F.
Fraga, M.
Albuquerque, M.
Facucho, J.
Espada, P.
Paulino, S.
Cintra, P.
EUROPEAN PSYCHIATRY, 2023, 66 : S1048 - S1048
[46] First episode psychosis: the depressive symptoms and suicidal behaviour that follow
Mesquita, B. L. B.
Ribeirinho Soares, F.
Fraga, M.
Albuquerque, M.
Facucho, J.
Espada, P.
Paulino, S.
Cintra, P.
EUROPEAN PSYCHIATRY, 2023, 66 : S1048 - S1048
[47] Efficacy of Lurasidone in First-Episode Psychosis: Patient Phenotypes, Dosage, and Recommendations from an Expert Panel
Bernardo, Miquel
Marsa, Marina Diaz
Gonzalez-Pinto, Ana
Carrasco, Manuel Martin
Sola, Victor Perez
Saiz, Pilar Alejandra
Vieta, Eduard
Torrens, Marta
Arango, Celso
Crespo-Facorro, Benedicto
NEUROLOGY AND THERAPY, 2025, 14 (01) : 85 - 98
[48] Treating a Case of First-Episode Psychosis to Uncover Undiagnosed Obsessive Compulsive Disorder: A Case Report
Wazir, Larayeb
Astacio, Dario A.
Lind, Suzanne M.
CUREUS JOURNAL OF MEDICAL SCIENCE, 2023, 15 (06)
[49] Clarifying the diversity of first-episode psychosis: Neuropsychological correlates of clinical symptoms
Lindsberg, Jenni
Poutiainen, Erja
Kalska, Hely
NORDIC JOURNAL OF PSYCHIATRY, 2009, 63 (06) : 493 - 500
[50] Extrapyramidal symptoms predict cognitive performance after first-episode psychosis
Maija Lindgren
Sebastian Therman
Anna Avellan
Tiina From
Jarmo Hietala
Minna Holm
Tuula Ilonen
Tuula Kieseppä
Heikki Laurikainen
Raimo K. R. Salokangas
Jaana Suvisaari
Schizophrenia, 8

← 1 2 3 4 5 →