Lurasidone in first-episode psychosis with predominant depressive symptoms: a case report

被引：4

作者：

Ricci, Valerio ^{[1
,3
]}

Di Salvo, Gabriele ^{[2
]}

Maina, Giuseppe ^{[2
]}

机构：

[1] San Luigi Gonzaga Univ Hosp, Dept Psychiat, Orbassano, Regione Gonzole, Italy

[2] Univ Turin, Rita Levi Montalcini Dept Neurosci, Turin, Italy

[3] San Luigi Gonzaga Univ Hosp, Dept Psychiat, Reg Gonzole 10, I-10043 Turin, Italy

来源：

INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY | 2023年 / 38卷 / 04期

关键词：

depression; first-episode psychosis; lurasidone; negative symptoms; psychotic symptoms; schizophrenia; SCHIZOPHRENIA; 5-HT7;

D O I：

10.1097/YIC.0000000000000465

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Lurasidone is an atypical antipsychotic approved for the treatment of schizophrenia and bipolar depression. It seems to have an antidepressant effect due to 5-HT7 as well as 5-HT2A and 5-HT1a receptor affinity. Here we present a case of a 19-year-old male patient with first-episode psychosis (FEP) and predominant depressive symptoms. Remarkable clinical and functional improvement was observed 3 months after the beginning of lurasidone treatment. The patient's depressive symptoms disappear with a dramatic reduction of psychotic ones, with good tolerance of the drug and without adverse effects. Lurasidone seems to be a promising treatment option for FEP with predominant depressive symptoms.

引用

页码：275 / 280

页数：6

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