Palladium-Catalyzed Oxidative Annulation Leading to Substituted Pyrrolo[3,2,1-jk]carbazoles by Sequential C-N and C-C Bond Formation

被引：2
|
作者：
Azizzade, Meysam [1 ]
Ranjbar, Parviz Rashidi [1 ]
Sajadi, Akram [1 ]
机构：
[1] Univ Tehran, Sch Chem, Coll Sci, Tehran 141556455, Iran
来源：
ORGANIC LETTERS | 2023年 / 25卷 / 11期
关键词：
PROPARGYL ALCOHOLS; CYCLOADDITION; ACTIVATION; INDOLES; ALKYNES; ACCESS;
D O I：
10.1021/acs.orglett.3c00244
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel regioselective annulation of propargylic alcohols with simple carbazoles for the construction of [3,2,1-jk]carbazole scaffolds is described to be the first example of intermolecular synthesis of [3,2,1-jk]carbazoles from simple carbazoles. In situ synthesis of propargyl alcohols from simple, cheap, and easily accessible ketones has also been developed during the one-pot synthesis of [3,2,1-jk]carbazoles. ??? R1 ??? Facile access to raw materials ??? Ligand-, Base-, and Silver-free reaction ??? One-pot tandem reaction ??? Up to 97% isolated yield, grain scalable R2,` R3 Pd/C R1 AromatIzatl n R1
引用
收藏
页码：1823 / 1828
页数：6
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