The synthesis of N-arylcyclopropylamines via palladium-catalyzed C-N bond formation

被引：26
|
作者：
Cui, W [1 ]
Loeppky, RN [1 ]
机构：
[1] Univ Missouri, Dept Chem, Columbia, MO 65211 USA
来源：
TETRAHEDRON | 2001年 / 57卷 / 15期
关键词：
cyclopropylamine; N-arylcyclopropylamine; N-arylation; Pd catalysis;
D O I：
10.1016/S0040-4020(01)00118-1
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A variety of N-arylcyclopropylamines has been prepared in one step, by the Pd-2(dba)(3)/BINAP/NaOtBu-catalyzed amination of an aryl bromide with cyclopropylamine. Compounds bearing the N-aryl substitutent (phenyl, 4-methylphenyl, 2-methoxyphenyl, 3-methoxyphenyl, 4-chlorophenyl, 1-napthyl, 9-anthryl, 9-phenanthryl, and 3-pyridyl) were prepared in isolated yields ranging from 43 to 99%. Overall, this chemistry represents a vast improvement over the previous multi-step procedures for the synthesis of compounds of this type. (C) 2001 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：2953 / 2956
页数：4
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