Discovery of a RIPK2 Scaffolding Inhibitor for the Treatment of Joint Autoimmune Diseases

被引:0
|
作者
Wlodarska, Marta [1 ]
Van Huis, Chad [2 ]
Hoss, Florian [3 ]
Meyer, Rosana [1 ]
Lu, Xiaokang [2 ]
Koelmel, Dominik [2 ]
Sanchez, Brian [2 ]
Lesch, Chuck [2 ]
Telling, Alissa [2 ]
Minns, Martin [1 ]
Mbah, Nneka [2 ]
Lacan, Isabelle [1 ]
Aversa, Robert [1 ]
Lesburg, Charles [1 ]
Yu, Carmen [2 ]
Soisson, Stephen [1 ]
Dales, Natalie [1 ]
Patrick, Darryl [1 ]
Opipari, Anthony [2 ]
Pan, Shifeng [4 ]
Franchi, Luigi [2 ]
机构
[1] Odyssey Therapeut, Boston, MA USA
[2] Odyssey Therapeut, Ann Arbor, MI USA
[3] Odyssey Therapeut, Frankfurt, Germany
[4] Odyssey Therapeut, San Diego, CA USA
关键词
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
0061
引用
收藏
页码:102 / 103
页数:2
相关论文
共 50 条
  • [41] Discovery of Lanraplenib (GS-9876): A Once-Daily Spleen Tyrosine Kinase Inhibitor for Autoimmune Diseases
    Blomgren, Peter
    Chandrasekhar, Jayaraman
    Di Paolo, Julie A.
    Fung, Wanchi
    Geng, Guoju
    Ip, Carmen
    Jones, Randall
    Kropf, Jeffrey E.
    Lansdon, Eric B.
    Lee, Seung
    Lo, Jennifer R.
    Mitchell, Scott A.
    Murray, Bernard
    Pohlmeyer, Chris
    Schmitt, Aaron
    Suekawa-Pirrone, Kimberly
    Wise, Sarah
    Xiong, Jin-Ming
    Xu, Jianjun
    Yu, Helen
    Zhao, Zhongdong
    Currie, Kevin S.
    ACS MEDICINAL CHEMISTRY LETTERS, 2020, 11 (04): : 506 - 513
  • [42] Discovery of the TYK2 selective inhibitor PF-6826647 for the treatment of Crohn's disease, and other autoimmune conditions
    Gerstenberger, Brian
    Arnold, Eric
    Banker, Mary Ellen
    Brown, Matthew
    Clark, James
    Dermenci, Alpay
    Dowty, Martin
    Fensome, Andrew
    Hayward, Matthew
    Hegen, Martin
    Hollingshead, Brett
    Knafels, John
    Lin, David
    Lin, Tsung
    Owen, Dafydd
    Saiah, Eddine
    Sharma, Raman
    Vajdos, Felix
    Vincent, Fabien
    Wright, Stephen
    Xing, Li
    Yang, Xiaojing
    Yang, Xin
    Zhang, Liying
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2018, 256
  • [43] Discovery of a Novel Inhaled PI3Kδ Inhibitor for the Treatment of Respiratory Diseases
    Erra, Montse
    Taltavull, Joan
    Javier Bernal, Francisco
    Francisco Caturla, Juan
    Carrascal, Marta
    Pages, Lluis
    Mir, Marta
    Espinosa, Sonia
    Gracia, Jordi
    Dominguez, Maria
    Sabate, Mar
    Paris, Stephane
    Maldonado, Monica
    Hernandez, Begona
    Bravo, Monica
    Calama, Elena
    Miralpeix, Montserrat
    Lehner, Martin D.
    Calbet, Marta
    JOURNAL OF MEDICINAL CHEMISTRY, 2018, 61 (21) : 9551 - 9567
  • [44] Golimumab: A human anti-TNF-alpha monoclonal antibody for the treatment of autoimmune joint diseases
    Phung, Olivia J.
    Coleman, Craig I.
    FORMULARY, 2009, 44 (09) : 264 - +
  • [45] Characterization of a small molecule IRAK4 kinase inhibitor for the treatment of autoimmune and inflammatory diseases
    Lamagna, Chrystelle
    Chan, Meagan
    Yi, Sothy
    Young, Chi
    Frances, Roy
    Siu, Stacey
    Braselmann, Sylvia
    Payan, Donald G.
    McMurtrie, Darren
    Kelley, Ryan
    Heckrodt, Thilo
    Yen, Rose
    Chen, Yan
    Li, Hui
    Singh, Rajinder
    Park, Gary
    Masuda, Esteban
    Taylor, Vanessa
    JOURNAL OF IMMUNOLOGY, 2016, 196
  • [46] A novel specific inhibitor of PI3Kδ as a potential treatment for autoimmune blistering diseases
    Balague, C.
    Koga, H.
    Kasprick, A.
    Ludwig, R.
    Pont, M.
    Lopez, R.
    Auli, M.
    Godessart, N.
    EXPERIMENTAL DERMATOLOGY, 2015, 24 (12) : 984 - 984
  • [47] Discovery and Characterization of a Selective, Orally Bioavailable PAD4 Inhibitor to Target NETs Driven Autoimmune and Inflammatory Diseases
    Yang, Min
    Feng, song
    Wen, Yuling
    Ren, Xiaoming
    Li, Huijuan
    Yao, lili
    xie, Zhi
    zhong, Wenge
    ARTHRITIS & RHEUMATOLOGY, 2023, 75 : 81 - 82
  • [48] ShK-186 from Discovery to Clinical Development for the Treatment of Multiple Sclerosis and Other Autoimmune Diseases
    Pennington, M. W.
    Chandy, K. G.
    Beeton, C.
    Iodonato, S.
    Tarcha, E.
    Norton, R. S.
    BIOPOLYMERS, 2013, 100 (03) : 237 - 237
  • [49] Discovery of the TLR7/8 Antagonist MHV370 for Treatment of Systemic Autoimmune Diseases
    Alper, Phil
    Betschart, Claudia
    Andre, Ceïdric
    Boulay, Thomas
    Cheng, Dai
    Deane, Jonathan
    Faller, Michael
    Feifel, Roland
    Glatthar, Ralf
    Han, Dong
    Hemmig, Rene
    Jiang, Tao
    Knoepfel, Thomas
    Maginnis, Jillian
    Mutnick, Daniel
    Pei, Wei
    Ruzzante, Giulia
    Syka, Peter
    Zhang, Guobao
    Zhang, Yi
    Zink, Florence
    Zipfel, Geraldine
    Hawtin, Stuart
    Junt, Tobias
    Michellys, Pierre-Yves
    ACS MEDICINAL CHEMISTRY LETTERS, 2023, 14 (08): : 1054 - 1062
  • [50] Structures of EBI2 shed light on the treatment of autoimmune diseases
    Shen, Jinkang
    Zhang, Haitao
    STRUCTURE, 2022, 30 (07) : 922 - 924