Assimiloside A, a Glycolipid with Immunomodulatory Activity from the Northwestern Pacific Marine Sponge Hymeniacidon assimilis

被引:4
|
作者
Kudryashova, Ekaterina K. [1 ]
Makarieva, Tatyana N. [1 ]
Shubina, Larisa K. [1 ]
Guzii, Alla G. [1 ]
Popov, Roman S. [1 ]
Menshov, Alexander S. [1 ]
Berdyshev, Dmitrii V. [1 ]
Pislyagin, Evgeny A. [1 ]
Menchinskaya, Ekaterina S. [1 ]
Grebnev, Boris B. [1 ]
Stonik, Valentin A. [1 ]
机构
[1] Russian Acad Sci, G B Elyakov Pacific Inst Bioorgan Chem, Far Eastern Branch, Vladivostoku 690022, Russia
来源
JOURNAL OF NATURAL PRODUCTS | 2023年
基金
俄罗斯科学基金会;
关键词
RESIN GLYCOSIDES;
D O I
10.1021/acs.jnatprod.3c00456
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
AssimilosideA (1), an unprecedented marine glycolipidcontaining a & gamma;-lactone of 4R,16,26R-trihydroxy C-28 fatty acid as an aglycon and a trisaccharidecarbohydrate moiety, was isolated from the marine sponge Hymeniacidonassimilis. Its structure was elucidated by NMR spectroscopy,mass spectrometry, chemical transformations, and ECD spectroscopycombined with time-dependent density functional theory calculations.Assimiloside A at nontoxic concentrations of 0.01-0.1 & mu;Mwas shown to present lysosomal activity stimulation and intracellularreactive oxygen species level elevation in RAW 264.7 murine macrophages.
引用
收藏
页码:2073 / 2078
页数:6
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