Assimiloside A, a Glycolipid with Immunomodulatory Activity from the Northwestern Pacific Marine Sponge Hymeniacidon assimilis

被引：4

作者：

Kudryashova, Ekaterina K. ^{[1
]}

Makarieva, Tatyana N. ^{[1
]}

Shubina, Larisa K. ^{[1
]}

Guzii, Alla G. ^{[1
]}

Popov, Roman S. ^{[1
]}

Menshov, Alexander S. ^{[1
]}

Berdyshev, Dmitrii V. ^{[1
]}

Pislyagin, Evgeny A. ^{[1
]}

Menchinskaya, Ekaterina S. ^{[1
]}

Grebnev, Boris B. ^{[1
]}

Stonik, Valentin A. ^{[1
]}

机构：

[1] Russian Acad Sci, G B Elyakov Pacific Inst Bioorgan Chem, Far Eastern Branch, Vladivostoku 690022, Russia

来源：

JOURNAL OF NATURAL PRODUCTS | 2023年

基金：

俄罗斯科学基金会;

关键词：

RESIN GLYCOSIDES;

D O I：

10.1021/acs.jnatprod.3c00456

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

AssimilosideA (1), an unprecedented marine glycolipidcontaining a & gamma;-lactone of 4R,16,26R-trihydroxy C-28 fatty acid as an aglycon and a trisaccharidecarbohydrate moiety, was isolated from the marine sponge Hymeniacidonassimilis. Its structure was elucidated by NMR spectroscopy,mass spectrometry, chemical transformations, and ECD spectroscopycombined with time-dependent density functional theory calculations.Assimiloside A at nontoxic concentrations of 0.01-0.1 & mu;Mwas shown to present lysosomal activity stimulation and intracellularreactive oxygen species level elevation in RAW 264.7 murine macrophages.

引用

页码：2073 / 2078

页数：6

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