Ru(II)-Catalyzed One-Pot Synthesis of 1,2-Hydropyridines via a Three-Component Reaction

被引：1
|
作者：
Yang, Juntao [1 ]
Liu, Bingxian [1 ]
Chang, Junbiao [1 ]
机构：
[1] Henan Normal Univ, Sch Chem & Chem Engn, NMPA Key Lab Res & Evaluat Innovat Drug, Xinxiang 453007, Henan, Peoples R China
来源：
ORGANIC LETTERS | 2023年 / 25卷 / 09期
基金：
国家重点研发计划; 中国博士后科学基金;
关键词：
H BOND ACTIVATION; STEREOSELECTIVE-SYNTHESIS; HETEROCYCLES; ANNULATION; PYRIDINE; ALKYNES; UTILITY; IMINES;
D O I：
10.1021/acs.orglett.3c00216
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A ruthenium(II)-catalyzed one-pot synthesis of highly substituted 1,2-dihydropyridines (DHPs) via a three component reaction system has been realized. The reaction is conducted using a simple Ru(II) catalyst without the addition of specific ligands. The catalytic system exhibits good functionality tolerance with a wide range of starting materials. The DHPs obtained can be easily converted into tetrahydropyridines and azabicyclo[4.2.0]octa-4,7-dienes by subsequent reduction or [2 + 2] cycloaddition reaction.
引用
收藏
页码：1476 / 1480
页数：5
相关论文
共 50 条
  • [41] One-pot Three-component Synthesis of Spirooxindoles Catalyzed by Nano Ag/kaolin
    Sadeghi, Bahareh
    Lasemi, Zahra
    Azimi, Razieh
    ORIENTAL JOURNAL OF CHEMISTRY, 2015, 31 (02) : 1175 - 1179
  • [42] NANOCRYSTALLINE COPPER(II) OXIDE-CATALYZED ONE-POT SYNTHESIS OF IMIDAZO[1,2-a]QUINOLINE AND QUINOLINO[1,2-a]QUINAZOLINE DERIVATIVES VIA A THREE-COMPONENT CONDENSATION
    Ahmadi, Seyed Javad
    Hosseinpour, Morteza
    Sadjadi, Sodeh
    SYNTHETIC COMMUNICATIONS, 2011, 41 (03) : 426 - 435
  • [43] Efficient synthesis of novel imidazo[1,2-a]pyrimidine derivatives via one-pot three-component procedure
    Sadjadi, Samahe
    Nahavandi, Fatemeh
    Heravi, Majid M.
    JOURNAL OF THE IRANIAN CHEMICAL SOCIETY, 2015, 12 (06) : 1049 - 1052
  • [44] Efficient synthesis of novel imidazo[1,2-a]pyrimidine derivatives via one-pot three-component procedure
    Samahe Sadjadi
    Fatemeh Nahavandi
    Majid Heravi
    Journal of the Iranian Chemical Society, 2015, 12 : 1049 - 1052
  • [45] An Efficient Synthesis of N′-(Fluoroalkylsulfonyl) Amidines by a Copper(I)-Catalyzed One-Pot Three-Component Reaction
    Xiong, Wanting
    Xin, Yong
    Zhao, Jingwei
    Zhu, Shizheng
    SYNTHESIS-STUTTGART, 2011, (07): : 1142 - 1148
  • [46] Palladium-catalyzed one-pot synthesis of highly substituted furans by a three-component annulation reaction
    Duan, XH
    Liu, XY
    Guo, LN
    Liao, MC
    Liu, WM
    Liang, YM
    JOURNAL OF ORGANIC CHEMISTRY, 2005, 70 (17): : 6980 - 6983
  • [47] Camphorsulfonic Acid Catalyzed One-Pot Three-Component Reaction for the Synthesis of Fused Quinoline and Benzoquinoline Derivatives
    Gattu, Radhakrishna
    Bagdi, Prasanta Ray
    Basha, R. Sidick
    Khan, Abu T.
    JOURNAL OF ORGANIC CHEMISTRY, 2017, 82 (23): : 12416 - 12429
  • [48] Synthesis of Highly Substituted 4H-Pyrido[1,2-a]pyrimidines via a One-Pot Three-Component Condensation Reaction
    Yang, Kai
    Xiang, Jinbao
    Bao, Guochen
    Dang, Qun
    Bai, Xu
    ACS COMBINATORIAL SCIENCE, 2013, 15 (09) : 519 - 524
  • [49] Copper(II) Catalyzed Expeditious Synthesis of Furoquinoxalines through a One-Pot Three-Component Coupling Strategy
    Naresh, Gunaganti
    Kant, Ruchir
    Narender, Tadigoppula
    ORGANIC LETTERS, 2014, 16 (17) : 4528 - 4531
  • [50] A Novel and Efficient Synthesis of Pyrido[1,2-a]-Fused 1,3-Diazaheterocyclic Compounds via a One-Pot Three-Component Reaction
    Alizadeh, Abdolali
    Rezvanian, Atieh
    HELVETICA CHIMICA ACTA, 2012, 95 (01) : 152 - 156
12345