Ru(II)-Catalyzed One-Pot Synthesis of 1,2-Hydropyridines via a Three-Component Reaction

被引：1
|
作者：
Yang, Juntao [1 ]
Liu, Bingxian [1 ]
Chang, Junbiao [1 ]
机构：
[1] Henan Normal Univ, Sch Chem & Chem Engn, NMPA Key Lab Res & Evaluat Innovat Drug, Xinxiang 453007, Henan, Peoples R China
来源：
ORGANIC LETTERS | 2023年 / 25卷 / 09期
基金：
国家重点研发计划; 中国博士后科学基金;
关键词：
H BOND ACTIVATION; STEREOSELECTIVE-SYNTHESIS; HETEROCYCLES; ANNULATION; PYRIDINE; ALKYNES; UTILITY; IMINES;
D O I：
10.1021/acs.orglett.3c00216
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A ruthenium(II)-catalyzed one-pot synthesis of highly substituted 1,2-dihydropyridines (DHPs) via a three component reaction system has been realized. The reaction is conducted using a simple Ru(II) catalyst without the addition of specific ligands. The catalytic system exhibits good functionality tolerance with a wide range of starting materials. The DHPs obtained can be easily converted into tetrahydropyridines and azabicyclo[4.2.0]octa-4,7-dienes by subsequent reduction or [2 + 2] cycloaddition reaction.
引用
收藏
页码：1476 / 1480
页数：5
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