NT-proBNP/urine hepcidin-25 ratio and cardiorenal syndrome type 1 in patients with severe symptomatic aortic stenosis

被引：2

作者：

Nuebel, Jonathan ^{[1
,2
]}

Hoffmeister, Meike ^{[3
,4
,5
]}

Labrenz, Oliver ^{[6
]}

Jost, Kerstin ^{[6
]}

Oess, Stefanie ^{[3
,4
,5
]}

Hauptmann, Michael ^{[4
,5
,7
]}

Schoen, Julika ^{[8
]}

Fritz, Georg ^{[9
]}

Haase, Michael ^{[10
,11
,12
]}

Butter, Christian ^{[1
,2
,4
,5
]}

Haase-Fielitz, Anja ^{[1
,2
,4
,5
,12
]}

机构：

[1] Univ Hosp Heart Ctr Brandenburg, Dept Cardiovasc, D-16321 Bernau, Germany

[2] Brandenburg Med Sch MHB, Fac Hlth Sci Brandenburg, D-16321 Bernau, Germany

[3] Brandenburg Med Sch MHB, Inst Biochem, D-14770 Brandenburg, Germany

[4] Univ Potsdam, Joint Fac, Fac Hlth Sci FGW, Brandenburg Med Sch, Cottbus, Germany

[5] Brandenburg Tech Univ Cottbus Senftenberg, Cottbus, Germany

[6] Univ Hosp Ruppin Brandenburg, Brandenburg Med Sch MHB, Dept Psychol, D-16816 Neuruppin, Germany

[7] Brandenburg Med Sch MHB, Inst Biostat & Registry Res, D-16816 Neuruppin, Germany

[8] Univ Hosp Ruppin Brandenburg, Brandenburg Med Sch MHB, Anesthesia & Intens Care, D-16816 Neuruppin, Germany

[9] Univ Hosp Heart Ctr Brandenburg, Brandenburg Med Sch MHB, Dept Anesthesiol Intens Care & Pain Therapy, D-16321 Bernau, Germany

[10] Diamedikum Kidney Care Ctr, D-14473 Potsdam, Germany

[11] Hannover Med Sch, Dept Nephrol & Hypertens, DE-30625 Hannover, Germany

[12] Otto von Guericke Univ, Inst Social Med & Hlth Syst Res, D-39120 Magdeburg, Germany

来源：

BIOMARKERS IN MEDICINE | 2023年 / 17卷 / 10期

关键词：

acute kidney injury; aortic stenosis; biomarker ratio; cardiorenal syndrome; hepcidin; NT-proBNP; TAVI; ACUTE KIDNEY INJURY; CONSENSUS CONFERENCE; RISK; DEFINITIONS; BIOMARKERS; MANAGEMENT;

D O I：

10.2217/bmm-2023-0034

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Background: This study aimed to determine whether novel and conventional cardiorenal biomarkers in patients before transcatheter aortic valve implantation may be associated with cardiorenal syndrome (CRS) type 1. Methods: Serum NT-proBNP and urine biomarkers (hepcidin-25, NGAL, IL-6) were measured before and 24 h after transcatheter aortic valve implantation. Results: 16/95 patients had CRS type 1. Those patients had longer length of stay in hospital (12.5 [9.0-16.0] vs 9.0 [8-12] days; p = 0.025) and were more frequently readmitted to hospital within 6 months after discharge (46.7 vs 15.6%; odds ratio: 4.7; 95% CI: 1.5-15.5; p = 0.007). The NT-proBNP/urine hepcidin-25 ratio (odds ratio: 2.89; 95% CI: 1.30-6.41; p = 0.009) was an independent modifier of CRS type 1. Conclusion: The NT-proBNP/urine hepcidin-25 ratio appears to be a modifier of risk of CRS type 1.

引用

页码：475 / 485

页数：11

共 50 条

[41] The association between hs-CRP, hs-TnT and NT-proBNP, and all-cause mortality in operated versus non-operated patients with severe aortic valve stenosis.
Auensen, A.
Hussain, A. I.
Pettersen, K. I.
Ueland, T.
Gullestad, L.
EUROPEAN JOURNAL OF HEART FAILURE, 2016, 18 : 80 - 80
[42] The frailty syndrome and mortality among very old patients with symptomatic severe aortic stenosis under different treatments
Rodriguez-Pascual, Carlos
Paredes-Galan, Emilio
Isabel Ferrero-Martinez, Ana
Antonio Baz-Alonso, Jose
Duran-Munoz, Dario
Gonzalez-Babarro, Eva
Sanmartin, Marcelo
Parajes, Teresa
Torres-Torres, Ivett
Pinon-Esteban, Miguel
Calvo-Iglesias, Francisco
Teresa Olcoz-Chiva, Maria
Rodriguez-Artalejo, Fernando
INTERNATIONAL JOURNAL OF CARDIOLOGY, 2016, 224 : 125 - 131
[43] Diagnostic and prognostic value of N-terminal pro B-type natriuretic peptide (NT-proBNP) in patients with chronic aortic regurgitation
Weber, Michael
Hausen, Michael
Arnold, Roman
Moellmann, Helge
Nef, Holger
Elsaesser, Albrecht
Mitrovic, Vesselin
Hamm, Christian
INTERNATIONAL JOURNAL OF CARDIOLOGY, 2008, 127 (03) : 321 - 327
[44] Predictive Value of the Lipoprotein(a) to Prealbumin Ratio and of the NT-proBNP to LVEF Ratio for Major Adverse Cardiovascular Events Following Percutaneous Coronary Intervention in Patients with Acute Coronary Syndrome
Zhang, Yingqian
Shi, Fangyuan
HEART SURGERY FORUM, 2023, 26 (05): : E470 - E477
[45] NT-proBNP is a potent prognostic marker in patients with type 2 diabetes hospitalized for acute coronary syndrome - a DIGAMI 2 sub study
Gustafsson, I.
Mellbin, L.
Dickstein, K.
Malmberg, K.
Ryden, L.
Torp-Pedersen, C.
Wedel, H.
Hildebrandt, P.
EUROPEAN HEART JOURNAL, 2010, 31 : 514 - 515
[46] Hemorrhagic Fever with Renal Syndrome Patients Exhibit Increased Levels of Lipocalin-2, Endothelin-1 and NT-proBNP
Krajinovic, Lidija Cvetko
Bodulic, Kristian
Laskaj, Renata
Zibrat, Branka
Karic, Petra Svoboda
Kurolt, Ivan-Christian
Kordun, Mihaela
Topic, Antea
Civljak, Rok
Skuhala, Tomislava
Markotic, Alemka
LIFE-BASEL, 2023, 13 (11):
[47] Teneligliptin Improved Postprandial Hyperglycemia without Severe Hypoglycemia and Increasing NT-proBNP in Japanese Patients with Type 2 Diabetes and Chronic Renal Failure
Tatsuoka, Hisato
Hamamoto, Yoshiyuki
Honjo, Sachiko
Fujimoto, Kanta
Matsuoka, Atsuko
Shibayama, Yui
Tokumoto, Shinsuke
Yamaguchi, Eriko
Ikeda, Hiroki
Wada, Yoshiharu
Koshiyama, Hiroyuki
DIABETES, 2014, 63 : A612 - A612
[48] Effects of Phosphodiesterase Type 5 Inhibition on Systemic and Pulmonary Hemodynamics and Ventricular Function in Patients With Severe Symptomatic Aortic Stenosis
Lindman, Brian R.
Zajarias, Alan
Madrazo, Jose A.
Shah, Jay
Gage, Brian F.
Novak, Eric
Johnson, Stephanie N.
Chakinala, Murali M.
Hohn, Tara A.
Saghir, Mohammed
Mann, Douglas L.
CIRCULATION, 2012, 125 (19) : 2353 - +
[49] Cardiac function and mass in asymptomatic type 1 diabetic patients with diabetic nephropathy in relation to NT-proBNP - a cardiovascular magnetic resonance study
Astrup, AS
Kim, WY
Tarnow, L
Falk, E
Botnar, R
Simonsen, C
Brix, L
Pietraszek, L
Hansen, PR
Manning, WJ
Parving, HH
DIABETOLOGIA, 2005, 48 : A8 - A9
[50] Polymorphisms in the B-type natriuretic peptide (BNP) gene are associated with NT-proBNP levels but not with diabetic nephropathy or mortality in type 1 diabetic patients
Lajer, Maria
Tarnow, Lise
Jorsal, Anders
Parving, Hans-Henrik
NEPHROLOGY DIALYSIS TRANSPLANTATION, 2007, 22 (11) : 3235 - 3239

← 1 2 3 4 5 →