NT-proBNP/urine hepcidin-25 ratio and cardiorenal syndrome type 1 in patients with severe symptomatic aortic stenosis

被引：2

作者：

Nuebel, Jonathan ^{[1
,2
]}

Hoffmeister, Meike ^{[3
,4
,5
]}

Labrenz, Oliver ^{[6
]}

Jost, Kerstin ^{[6
]}

Oess, Stefanie ^{[3
,4
,5
]}

Hauptmann, Michael ^{[4
,5
,7
]}

Schoen, Julika ^{[8
]}

Fritz, Georg ^{[9
]}

Haase, Michael ^{[10
,11
,12
]}

Butter, Christian ^{[1
,2
,4
,5
]}

Haase-Fielitz, Anja ^{[1
,2
,4
,5
,12
]}

机构：

[1] Univ Hosp Heart Ctr Brandenburg, Dept Cardiovasc, D-16321 Bernau, Germany

[2] Brandenburg Med Sch MHB, Fac Hlth Sci Brandenburg, D-16321 Bernau, Germany

[3] Brandenburg Med Sch MHB, Inst Biochem, D-14770 Brandenburg, Germany

[4] Univ Potsdam, Joint Fac, Fac Hlth Sci FGW, Brandenburg Med Sch, Cottbus, Germany

[5] Brandenburg Tech Univ Cottbus Senftenberg, Cottbus, Germany

[6] Univ Hosp Ruppin Brandenburg, Brandenburg Med Sch MHB, Dept Psychol, D-16816 Neuruppin, Germany

[7] Brandenburg Med Sch MHB, Inst Biostat & Registry Res, D-16816 Neuruppin, Germany

[8] Univ Hosp Ruppin Brandenburg, Brandenburg Med Sch MHB, Anesthesia & Intens Care, D-16816 Neuruppin, Germany

[9] Univ Hosp Heart Ctr Brandenburg, Brandenburg Med Sch MHB, Dept Anesthesiol Intens Care & Pain Therapy, D-16321 Bernau, Germany

[10] Diamedikum Kidney Care Ctr, D-14473 Potsdam, Germany

[11] Hannover Med Sch, Dept Nephrol & Hypertens, DE-30625 Hannover, Germany

[12] Otto von Guericke Univ, Inst Social Med & Hlth Syst Res, D-39120 Magdeburg, Germany

来源：

BIOMARKERS IN MEDICINE | 2023年 / 17卷 / 10期

关键词：

acute kidney injury; aortic stenosis; biomarker ratio; cardiorenal syndrome; hepcidin; NT-proBNP; TAVI; ACUTE KIDNEY INJURY; CONSENSUS CONFERENCE; RISK; DEFINITIONS; BIOMARKERS; MANAGEMENT;

D O I：

10.2217/bmm-2023-0034

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Background: This study aimed to determine whether novel and conventional cardiorenal biomarkers in patients before transcatheter aortic valve implantation may be associated with cardiorenal syndrome (CRS) type 1. Methods: Serum NT-proBNP and urine biomarkers (hepcidin-25, NGAL, IL-6) were measured before and 24 h after transcatheter aortic valve implantation. Results: 16/95 patients had CRS type 1. Those patients had longer length of stay in hospital (12.5 [9.0-16.0] vs 9.0 [8-12] days; p = 0.025) and were more frequently readmitted to hospital within 6 months after discharge (46.7 vs 15.6%; odds ratio: 4.7; 95% CI: 1.5-15.5; p = 0.007). The NT-proBNP/urine hepcidin-25 ratio (odds ratio: 2.89; 95% CI: 1.30-6.41; p = 0.009) was an independent modifier of CRS type 1. Conclusion: The NT-proBNP/urine hepcidin-25 ratio appears to be a modifier of risk of CRS type 1.

引用

页码：475 / 485

页数：11

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