NT-proBNP/urine hepcidin-25 ratio and cardiorenal syndrome type 1 in patients with severe symptomatic aortic stenosis

被引：2
|
作者：
Nuebel, Jonathan [1 ,2 ]
Hoffmeister, Meike [3 ,4 ,5 ]
Labrenz, Oliver [6 ]
Jost, Kerstin [6 ]
Oess, Stefanie [3 ,4 ,5 ]
Hauptmann, Michael [4 ,5 ,7 ]
Schoen, Julika [8 ]
Fritz, Georg [9 ]
Haase, Michael [10 ,11 ,12 ]
Butter, Christian [1 ,2 ,4 ,5 ]
Haase-Fielitz, Anja [1 ,2 ,4 ,5 ,12 ]
机构：
[1] Univ Hosp Heart Ctr Brandenburg, Dept Cardiovasc, D-16321 Bernau, Germany
[2] Brandenburg Med Sch MHB, Fac Hlth Sci Brandenburg, D-16321 Bernau, Germany
[3] Brandenburg Med Sch MHB, Inst Biochem, D-14770 Brandenburg, Germany
[4] Univ Potsdam, Joint Fac, Fac Hlth Sci FGW, Brandenburg Med Sch, Cottbus, Germany
[5] Brandenburg Tech Univ Cottbus Senftenberg, Cottbus, Germany
[6] Univ Hosp Ruppin Brandenburg, Brandenburg Med Sch MHB, Dept Psychol, D-16816 Neuruppin, Germany
[7] Brandenburg Med Sch MHB, Inst Biostat & Registry Res, D-16816 Neuruppin, Germany
[8] Univ Hosp Ruppin Brandenburg, Brandenburg Med Sch MHB, Anesthesia & Intens Care, D-16816 Neuruppin, Germany
[9] Univ Hosp Heart Ctr Brandenburg, Brandenburg Med Sch MHB, Dept Anesthesiol Intens Care & Pain Therapy, D-16321 Bernau, Germany
[10] Diamedikum Kidney Care Ctr, D-14473 Potsdam, Germany
[11] Hannover Med Sch, Dept Nephrol & Hypertens, DE-30625 Hannover, Germany
[12] Otto von Guericke Univ, Inst Social Med & Hlth Syst Res, D-39120 Magdeburg, Germany
来源：
BIOMARKERS IN MEDICINE | 2023年 / 17卷 / 10期
关键词：
acute kidney injury; aortic stenosis; biomarker ratio; cardiorenal syndrome; hepcidin; NT-proBNP; TAVI; ACUTE KIDNEY INJURY; CONSENSUS CONFERENCE; RISK; DEFINITIONS; BIOMARKERS; MANAGEMENT;
D O I：
10.2217/bmm-2023-0034
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Background: This study aimed to determine whether novel and conventional cardiorenal biomarkers in patients before transcatheter aortic valve implantation may be associated with cardiorenal syndrome (CRS) type 1. Methods: Serum NT-proBNP and urine biomarkers (hepcidin-25, NGAL, IL-6) were measured before and 24 h after transcatheter aortic valve implantation. Results: 16/95 patients had CRS type 1. Those patients had longer length of stay in hospital (12.5 [9.0-16.0] vs 9.0 [8-12] days; p = 0.025) and were more frequently readmitted to hospital within 6 months after discharge (46.7 vs 15.6%; odds ratio: 4.7; 95% CI: 1.5-15.5; p = 0.007). The NT-proBNP/urine hepcidin-25 ratio (odds ratio: 2.89; 95% CI: 1.30-6.41; p = 0.009) was an independent modifier of CRS type 1. Conclusion: The NT-proBNP/urine hepcidin-25 ratio appears to be a modifier of risk of CRS type 1.
引用
收藏
页码：475 / 485
页数：11
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