Electrochemical trifluoromethylation of 2-isocyanobiaryls using CF3SO2Na: synthesis of 6-(trifluoromethyl)phenanthridines

被引：9

作者：

La-ongthong, Kannika ^{[1
,2
]}

Chantarojsiri, Teera ^{[1
,2
]}

Soorukram, Darunee ^{[1
,2
]}

Leowanawat, Pawaret ^{[1
,2
]}

Reutrakul, Vichai ^{[1
,2
]}

Kuhakarn, Chutima ^{[1
,2
]}

机构：

[1] Mahidol Univ, Fac Sci, Dept Chem, Rama 6 Rd, Bangkok 10400, Thailand

[2] Mahidol Univ, Fac Sci, Ctr Excellence Innovat Chem PERCH CIC, Rama 6 Rd, Bangkok 10400, Thailand

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2023年 / 21卷 / 20期

关键词：

D O I：

10.1039/d3ob00239j

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient trifluoromethylation of 2-isocyanobiaryls was developed through the constant current electrolysis, employing sodium trifluoromethanesulfinate (CF3SO2Na) as the trifluoromethyl source. The method enabled the syntheses of a series of 6-(trifluoromethyl)phenanthridine derivatives in moderate to high yields under metal- and oxidant-free conditions. A gram-scale synthesis highlights the synthetic versatility of the reported protocol.

引用

页码：4225 / 4236

页数：13

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