Electrochemical trifluoromethylation of 2-isocyanobiaryls using CF3SO2Na: synthesis of 6-(trifluoromethyl)phenanthridines

被引：9
|
作者：
La-ongthong, Kannika [1 ,2 ]
Chantarojsiri, Teera [1 ,2 ]
Soorukram, Darunee [1 ,2 ]
Leowanawat, Pawaret [1 ,2 ]
Reutrakul, Vichai [1 ,2 ]
Kuhakarn, Chutima [1 ,2 ]
机构：
[1] Mahidol Univ, Fac Sci, Dept Chem, Rama 6 Rd, Bangkok 10400, Thailand
[2] Mahidol Univ, Fac Sci, Ctr Excellence Innovat Chem PERCH CIC, Rama 6 Rd, Bangkok 10400, Thailand
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2023年 / 21卷 / 20期
关键词：
D O I：
10.1039/d3ob00239j
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient trifluoromethylation of 2-isocyanobiaryls was developed through the constant current electrolysis, employing sodium trifluoromethanesulfinate (CF3SO2Na) as the trifluoromethyl source. The method enabled the syntheses of a series of 6-(trifluoromethyl)phenanthridine derivatives in moderate to high yields under metal- and oxidant-free conditions. A gram-scale synthesis highlights the synthetic versatility of the reported protocol.
引用
收藏
页码：4225 / 4236
页数：13
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