Genome doubling perturbs DNA packing and promotes cancer development

被引：0
|
作者：
Ben-David, Uri [1 ]
机构：
[1] Tel Aviv Univ, Tel Aviv, Israel
来源：
NATURE | 2023年
关键词：
Cancer; Epigenetics; Cell biology;
D O I：
10.1038/d41586-023-00426-1
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Cells in which the whole genome has been doubled do not upscale protein synthesis to cope with the increase in DNA. Instead, a shortage of proteins that regulate the packing of DNA in the nucleus leads to poor segregation of DNA structures, which eventually contributes to the development of cancer.
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页数：2
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