Genome doubling perturbs DNA packing and promotes cancer development

被引：0
|
作者：
Ben-David, Uri [1 ]
机构：
[1] Tel Aviv Univ, Tel Aviv, Israel
来源：
NATURE | 2023年
关键词：
Cancer; Epigenetics; Cell biology;
D O I：
10.1038/d41586-023-00426-1
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Cells in which the whole genome has been doubled do not upscale protein synthesis to cope with the increase in DNA. Instead, a shortage of proteins that regulate the packing of DNA in the nucleus leads to poor segregation of DNA structures, which eventually contributes to the development of cancer.
引用
收藏
页数：2
相关论文
共 50 条
  • [21] Thermodynamic energetics underlying genomic instability and whole-genome doubling in cancer
    Remacle, Francoise
    Graeber, Thomas G.
    Levine, R. D.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2020, 117 (31) : 18880 - 18890
  • [22] Disruption of KMT2D perturbs germinal center B cell development and promotes lymphomagenesis
    Jiyuan Zhang
    David Dominguez-Sola
    Shafinaz Hussein
    Ji-Eun Lee
    Antony B Holmes
    Mukesh Bansal
    Sofija Vlasevska
    Tongwei Mo
    Hongyan Tang
    Katia Basso
    Kai Ge
    Riccardo Dalla-Favera
    Laura Pasqualucci
    [J]. Nature Medicine, 2015, 21 : 1190 - 1198
  • [23] Disruption of KMT2D perturbs germinal center B cell development and promotes lymphomagenesis
    Zhang, Jiyuan
    Dominguez-Sola, David
    Hussein, Shafinaz
    Lee, Ji-Eun
    Holmes, Antony B.
    Bansal, Mukesh
    Vlasevska, Sofija
    Mo, Tongwei
    Tang, Hongyan
    Basso, Katia
    Ge, Kai
    Dalla-Favera, Riccardo
    Pasqualucci, Laura
    [J]. NATURE MEDICINE, 2015, 21 (10) : 1190 - +
  • [24] Genome-Wide Screening of Genes Regulated by DNA Methylation in Colon Cancer Development
    Spisak, Sandor
    Kalmar, Alexandra
    Galamb, Orsolya
    Wichmann, Barna
    Sipos, Ferenc
    Peterfia, Balint
    Csabai, Istvan
    Kovalszky, Ilona
    Semsey, Szabolcs
    Tulassay, Zsolt
    Molnar, Bela
    [J]. PLOS ONE, 2012, 7 (10):
  • [25] Peaceful revolution in genome size: polyploidy in the Nabidae (Heteroptera); autosomes and nuclear DNA content doubling
    Sadilek, David
    Vilimova, Jitka
    Urfus, Tomas
    [J]. ZOOLOGICAL JOURNAL OF THE LINNEAN SOCIETY, 2021, 193 (01) : 145 - 157
  • [26] Genome Size Doubling Arises From the Differential Repetitive DNA Dynamics in the Genus Heloniopsis (Melanthiaceae)
    Pellicer, Jaume
    Fernandez, Pol
    Fay, Michael F.
    Michalkova, Ester
    Leitch, Ilia J.
    [J]. FRONTIERS IN GENETICS, 2021, 12
  • [27] Interplay between whole-genome doubling and the accumulation of deleterious alterations in cancer evolution
    Saioa López
    Emilia L. Lim
    Stuart Horswell
    Kerstin Haase
    Ariana Huebner
    Michelle Dietzen
    Thanos P. Mourikis
    Thomas B. K. Watkins
    Andrew Rowan
    Sally M. Dewhurst
    Nicolai J. Birkbak
    Gareth A. Wilson
    Peter Van Loo
    Mariam Jamal-Hanjani
    Charles Swanton
    Nicholas McGranahan
    [J]. Nature Genetics, 2020, 52 : 283 - 293
  • [28] The Conjugative Relaxase TrwC Promotes Integration of Foreign DNA in the Human Genome
    Gonzalez-Prieto, Coral
    Gabriel, Richard
    Dehio, Christoph
    Schmidt, Manfred
    Llosa, Matxalen
    [J]. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2017, 83 (12)
  • [29] Interplay between whole-genome doubling and the accumulation of deleterious alterations in cancer evolution
    Lopez, Saioa
    Lim, Emilia L.
    Horswell, Stuart
    Haase, Kerstin
    Huebner, Ariana
    Dietzen, Michelle
    Mourikis, Thanos P.
    Watkins, Thomas B. K.
    Rowan, Andrew
    Dewhurst, Sally M.
    Birkbak, Nicolai J.
    Wilson, Gareth A.
    Van Loo, Peter
    Jamal-Hanjani, Mariam
    Swanton, Charles
    McGranahan, Nicholas
    [J]. NATURE GENETICS, 2020, 52 (03) : 283 - +
  • [30] Chronic Stress Promotes Cancer Development
    Dai, Shirui
    Mo, Yongzhen
    Wang, Yumin
    Xiang, Bo
    Liao, Qianjin
    Zhou, Ming
    Li, Xiaoling
    Li, Yong
    Xiong, Wei
    Li, Guiyuan
    Guo, Can
    Zeng, Zhaoyang
    [J]. FRONTIERS IN ONCOLOGY, 2020, 10
12345