Facile synthesis of 3-(pyrazol-1-yl) succinimides from Ag2CO3 -catalyzed aza-Michael addition of pyrazoles to maleimides

被引：1

作者：

Zhang, Xue ^{[1
]}

Mo, Jian ^{[1
]}

Luo, Da-Shuang ^{[1
]}

Niu, Xue-Min ^{[1
]}

Yu, Hai-Feng ^{[1
]}

Zhao, Xiao-Bo ^{[1
]}

机构：

[1] Baicheng Normal Univ, Coll Chem, POB 137000, Baicheng, Jilin, Peoples R China

来源：

SYNTHETIC COMMUNICATIONS | 2023年 / 53卷 / 24期

关键词：

Maleimide; Michael addition; pyrazole; silver carbonate; succinimide; DERIVATIVES; DISCOVERY; INDOLE;

D O I：

10.1080/00397911.2023.2270636

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Herein, an effective and facile synthesis of 3-(pyrazol-1-yl) succinimides is first presented through silver-catalyzed aza-Michael addition of pyrazoles to maleimides. In the presence of 5 mol% of Ag2CO3, various pyrazoles smoothly reacted with maleimides in dichloroethane at 100 degree celsius, to generate 3-(pyrazol-1-yl) succinimides in excellent yields. Notably, 3-substituted asymmetric pyrazoles exclusively give 3-pyrazolyl succinimides in excellent yields possibly due to the steric bulk of the 3-substituent excluding the formation of addition products of N-2. The method can also extend to gram scale.

引用

页码：2088 / 2096

页数：9

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