A case of dupilumab combination therapy for exacerbation of atopic dermatitis in a patient with eosinophilic granulomatosis with polyangiitis treated with mepolizumab

被引：4

作者：

Iwadate, Yosuke ^{[1
]}

Arinuma, Yoshiyuki ^{[1
]}

Matsueda, Yu ^{[1
]}

Tanaka, Tomoki ^{[1
]}

Wada, Tatuhiko ^{[1
]}

Tanaka, Sumiaki ^{[1
]}

Oku, Kenji ^{[1
]}

Yamaoka, Kunihiro ^{[1
]}

机构：

[1] Kitasato Univ, Sch Med, Dept Rheumatol & Infect Dis, Tokyo, Kanagawa, Japan

来源：

MODERN RHEUMATOLOGY CASE REPORTS | 2023年 / 8卷 / 01期

关键词：

Eosinophilic granulomatosis with polyangiitis (EGPA); atopic dermatitis (AD); mepolizumab; dupilumab;

D O I：

10.1093/mrcr/rxad059

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We report a 60-year-old male with eosinophilic granulomatosis with polyangiitis (EGPA) complicated with atopic dermatitis (AD). The patient was initially treated with prednisolone, cyclosporine A, and mepolizumab (MEPO). Due to worsening skin symptoms after prednisolone tapering, dupilumab (DUP) was added as an adjunctive therapy for AD confirmed by skin biopsy. The combination therapy of MEPO and DUP resulted in rapid improvement of skin symptoms, suggesting it may be an effective therapeutic option for patients with EGPA and AD. This case report emphasises the importance of a multidisciplinary approach in treating complex diseases such as EGPA and AD.

引用

页码：159 / 162

页数：4

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