A case of dupilumab combination therapy for exacerbation of atopic dermatitis in a patient with eosinophilic granulomatosis with polyangiitis treated with mepolizumab

被引：4
|
作者：
Iwadate, Yosuke [1 ]
Arinuma, Yoshiyuki [1 ]
Matsueda, Yu [1 ]
Tanaka, Tomoki [1 ]
Wada, Tatuhiko [1 ]
Tanaka, Sumiaki [1 ]
Oku, Kenji [1 ]
Yamaoka, Kunihiro [1 ]
机构：
[1] Kitasato Univ, Sch Med, Dept Rheumatol & Infect Dis, Tokyo, Kanagawa, Japan
来源：
MODERN RHEUMATOLOGY CASE REPORTS | 2023年 / 8卷 / 01期
关键词：
Eosinophilic granulomatosis with polyangiitis (EGPA); atopic dermatitis (AD); mepolizumab; dupilumab;
D O I：
10.1093/mrcr/rxad059
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
We report a 60-year-old male with eosinophilic granulomatosis with polyangiitis (EGPA) complicated with atopic dermatitis (AD). The patient was initially treated with prednisolone, cyclosporine A, and mepolizumab (MEPO). Due to worsening skin symptoms after prednisolone tapering, dupilumab (DUP) was added as an adjunctive therapy for AD confirmed by skin biopsy. The combination therapy of MEPO and DUP resulted in rapid improvement of skin symptoms, suggesting it may be an effective therapeutic option for patients with EGPA and AD. This case report emphasises the importance of a multidisciplinary approach in treating complex diseases such as EGPA and AD.
引用
收藏
页码：159 / 162
页数：4
相关论文
共 50 条
  • [1] Successful concomitant therapy with mepolizumab and dupilumab for atypical eosinophilic granulomatosis with polyangiitis
    Anai, Moriyasu
    Yoshida, Chieko
    Ozono, Kazutaka
    Furukawa, Hirotsugu
    Ishimaru, Yuko
    Sakata, Shinya
    Saruwatari, Koichi
    Muramoto, Kei
    Tomita, Yusuke
    Saeki, Sho
    Ichiyasu, Hidenori
    Sakagami, Takuro
    ALLERGOLOGY INTERNATIONAL, 2022, 71 (02) : 259 - 261
  • [2] Combination Biologic Therapy with Mepolizumab and Dupilumab for Severe Eosinophilic Granulomatosis with Polyangiitis and Chronic Rhinosinusitis with Nasal Polyp
    Nakamura, Yosuke
    Kikumoto, Naoki
    Takeuchi, Hiromi
    Kimura, Toru
    Nakamori, Motoki
    Fujiwara, Kazunori
    YONAGO ACTA MEDICA, 2024, 67 (02) : 157 - 162
  • [3] The effectiveness of combination maintenance therapy with mepolizumab and azathioprine for eosinophilic granulomatosis with polyangiitis
    Abe, Yoshiyuki
    Kogami, Masahiro
    Ando, Taiki
    Makiyama, Ayako
    Asanuma, Yuko
    Yamaji, Ken
    Tamura, Naoto
    INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES, 2024, 27 (09)
  • [4] A PATIENT WITH EOSINOPHILIC GRANULOMATOSIS WITH POLYANGIITIS TREATED ONLY WITH MEPOLIZUMAB AND INTRAVENOUS IMMUNOGLOBULIN
    Tamaki, Hiromichi
    Ikeda, Yukihiko
    Fukui, Sho
    Sawada, Haruki
    Kitada, Ayako
    Kawato, Rui
    Suda, Masei
    Yanaoka, Haruyuki
    Rokutanda, Ryo
    Shimizu, Hisanori
    Tsuda, Tokutaro
    Kishimoto, Mitsumasa
    Yamaguchi, Kenichi
    Okada, Masato
    RHEUMATOLOGY, 2019, 58
  • [5] A Pediatric Case of Relapsing Eosinophilic Granulomatosis with Polyangiitis Successfully Treated with Mepolizumab
    Nara, Mizuho
    Saito, Masaya
    Abe, Fumito
    Komatsuda, Atsushi
    Wakui, Hideki
    Takahashi, Naoto
    INTERNAL MEDICINE, 2019, 58 (24) : 3583 - 3587
  • [6] A case of solar urticaria complicated by eosinophilic granulomatosis with polyangiitis treated with mepolizumab
    Matsuda, Mayuko
    Nakajima, Kimiko
    Aoki, Natsuko
    Yamamoto, Mayuko
    Nakajima, Hideki
    Yamamoto, Hirotaka
    Taniguchi, Yoshinori
    Morizane, Shin
    Nakai, Kozo
    JOURNAL OF DERMATOLOGY, 2025, 52 (03): : e225 - e226
  • [7] Mepolizumab and Eosinophilic Pleural Effusion in Patient With Eosinophilic Granulomatosis With Polyangiitis
    Martinez, Maria del Carmen Lorenzo
    Garcia, Oscar Claveria
    Mendoza, Maria Dolores Herrero
    Esteban, Jose Javier Jareno
    ARCHIVOS DE BRONCONEUMOLOGIA, 2023, 59 (07): : 439 - 440
  • [8] MEPOLIZUMAB INDUCTION THERAPY FOR EOSINOPHILIC GRANULOMATOSIS WITH POLYANGIITIS (EGPA)
    Goldstein, M.
    Vadaketh, K.
    Dvorin, D.
    Belecanech, G.
    ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 2017, 119 (05) : S53 - S53
  • [9] Mepolizumab therapy in a pediatric patient with eosinophilic granulomatosis with polyangiitis associated with refractory myocarditis
    Ulu, Kadir
    Caglayan, Sengul
    Cetemen, Aysen
    Cakan, Mustafa
    Oner, Taliha
    Sozeri, Betul
    ARCHIVES OF RHEUMATOLOGY, 2023, 38 (02) : 326 - 328
  • [10] Isolated CNS involvement in eosinophilic granulomatosis with polyangiitis treated with mepolizumab: A case report
    Son, Hyoshin
    Lee, Woo-Jin
    Moon, Jangsup
    Yoon, Sungjoon
    Jung, Keun-Hwa
    Park, Kyung-Il
    Lee, Sang Kun
    Chu, Kon
    JOURNAL OF NEUROIMMUNOLOGY, 2021, 355
12345